دورية
Telomere Length and Reproductive Aging
| العنوان: | Telomere Length and Reproductive Aging |
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| المؤلفون: | Hanna, Courtney W., Bretherick, Karla L., Gair, Jane L., Fluker, Margo R., Stephenson, Mary D., Robinson, Wendy P. |
| المصدر: | Obstetrical and Gynecological Survey; October 2009, Vol. 64 Issue: 10 p663-664, 2p |
| مستخلص: | Previous studies have suggested an association between rates of biological and reproductive aging. Short telomere length is a marker for cellular aging and may occur more frequently in women with poor oocyte quality and a history of premature reproductive senescence. Telomere length, however, has been both positively and negatively associated with different measures of reproductive aging in a number of studies. In the present study, the investigators tested the hypothesis that women with a history of premature reproductive aging have a shorter average telomere length than women without such a history. Telomere length in peripheral blood leukocytes was measured in 2 groups of women with evidence of premature reproductive aging: Group 1 (n 34) was comprised of women with idiopathic premature ovarian failure (POF) who experienced menopause before 40 years of age and group 2 (n 95) contained women with a history of recurrent miscarriage (RM). The 2 control groups were healthy women of reproductive age from the general population (C1, n 108) and women who had had a healthy pregnancy after 37 years of age (C2, n 46). Telomere length was measured using telomere-specific quantitative PCR. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00297828 15339866 |
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| DOI: | 10.1097/01.ogx.0000359269.68606.cc |