التفاصيل البيبلوغرافية
| العنوان: |
Activity of two extracts of Cynanchum paniculatum against Ichthyophthirius multifiliis theronts and tomonts. |
| المؤلفون: |
JI-HONG, WEN, YAN-LI, WANG, YU-HUA, LIU, JI-YUAN, ZHANG, ZE-HONG, LI |
| المصدر: |
Parasitology; Feb2017, Vol. 144 Issue 2, p179-185, 7p |
| مصطلحات موضوعية: |
ICHTHYOPHTHIRIUS multifiliis, FISH diseases, CYTOCHEMICAL bioassay, ICHTHYOPHTHIRIIDAE, BIOLOGICAL assay |
| مستخلص: |
The present study aims to evaluate the antiparasitic activity of active components from Cynanchum paniculatum against Ichthyophthirius multifiliis. The antiparasitic activities of two bioassay-guided fractionationated compounds from C. paniculatum identified as Cynatratoside-A and Cynanversicoside C, by comparing spectral data (NMR and ESI-MS) with literature values, were evaluated by in vitro assay. These showed that both could kill theronts of I. multifiliis at a concentration of 10·0 mg L−1, with the median effective concentration (EC50) values of 4·6 mg L−1 and 5·2 mg L−1 for Cynatratoside-A and Cynanversicoside C, respectively. Encysted tomonts were killed at concentrations of 8·0 mg L−1 with both compounds. In vivo experiments demonstrated that fish treated with both compounds at 15·0 mg L−1 carried significantly fewer parasites than controls (P < 0·05). There were no mortalities among treated fish group compared with 75% mortality of untreated fish. Cynatratoside-A and Cynanversicoside C are therefore potential candidate drugs for use against I. multifiliis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
