دورية أكاديمية
Conservative versus surgical treatment of foot drop in peroneal nerve entrapment: rationale and design of a prospective, multi-centre, randomized parallel-group controlled trial
| العنوان: | Conservative versus surgical treatment of foot drop in peroneal nerve entrapment: rationale and design of a prospective, multi-centre, randomized parallel-group controlled trial |
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| المؤلفون: | Oosterbos, C., Rummens, S., Bogaerts, K., Hoornaert, S., Weyns, F., Dubuisson, Annie, Lemmens, R., Theys, T. |
| المصدر: | Trials, 23 (1) (2022) |
| بيانات النشر: | BioMed Central Ltd, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Conservative treatment, Foot drop, Neurolysis, Peroneal nerve, Protocol design, Randomized controlled trial, adult, ankle dorsiflexion angle, Article, clinical feature, comparative effectiveness, controlled study, European Quality of Life 5 Dimensions 5 Level questionnaire, female, functional status, human, major clinical study, male, multicenter study, nerve compression, nerve decompression, patient-reported outcome, peroneal nerve entrapment, peroneus nerve paralysis, prospective study, randomized controlled trial, risk factor, six minute walk test, ten minute walk test, walk test, ankle, clinical trial, paresis, peroneal neuropathy, treatment outcome, Ankle, Ankle Joint, Humans, Paresis, Peroneal Neuropathies, Prospective Studies, Treatment Outcome, Human health sciences, Surgery, Sciences de la santé humaine, Chirurgie |
| الوصف: | Background: High-quality evidence is lacking to support one treatment strategy over another in patients with foot drop due to peroneal nerve entrapment. This leads to strong variation in daily practice. Methods/design: The FOOTDROP (Follow-up and Outcome of Operative Treatment with Decompressive Release Of The Peroneal nerve) trial is a randomized, multi-centre study in which patients with peroneal nerve entrapment and persistent foot drop, despite initial conservative treatment, will be randomized 10 (± 4) weeks after onset between non-invasive treatment and surgical decompression. The primary endpoint is the difference in distance covered during the 6-min walk test between randomization and 9 months later. Time to recovery is the key secondary endpoint. Other secondary outcome measures encompass ankle dorsiflexion strength (MRC score and isometric dynamometry), gait assessment (10-m walk test, functional ambulation categories, Stanmore questionnaire), patient-reported outcome measures (EQ5D-5L), surgical complications, neurological deficits (sensory changes, motor scores for ankle eversion and hallux extension), health economic assessment (WPAI) and electrodiagnostic assessment. Discussion: The results of this randomized trial may elucidate the role of surgical decompression of the peroneal nerve and aid in clinical decision-making. Trial registration: ClinicalTrials.gov NCT04695834. Registered on 4 January 2021. © 2022, The Author(s). |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article peer reviewed |
| اللغة: | English |
| العلاقة: | urn:issn:1745-6215 |
| DOI: | 10.1186/s13063-022-07009-x |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/303696Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.303696 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1186/s13063-022-07009-x |
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