المصدر: Drug Week; 7/12/2024, p1472-1472, 1p

مصطلحات موضوعية: BRAIN metastasis, MACHINE learning, INDIVIDUALIZED medicine, RESEARCH personnel, STEREOTACTIC radiosurgery

مستخلص: Researchers from Tilburg University have conducted a systematic review of factors associated with the local control (LC) of brain metastases, with the aim of predicting treatment outcomes and improving overall survival. The study utilized machine learning algorithms to identify factors that influence LC and developed a predictive model for personalized treatment outcomes. The research found that higher radiation doses were associated with better LC in lung cancer, breast cancer, and melanoma groups, while higher tumor volume was associated with worse LC. The findings have potential translational value for clinicians in predicting treatment outcomes and adjusting treatment characteristics. [Extracted from the article]

: Copyright of Drug Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Immunotherapy Weekly; 7/9/2024, p1038-1038, 1p

مصطلحات موضوعية: BRAIN metastasis, STEREOTACTIC radiosurgery, UNIVERSITY research, BRAIN diseases, NEWSPAPER editors

الشركة/الكيان: UNIVERSITY of Texas M.D. Anderson Cancer Center

مستخلص: A recent study conducted by researchers at the University of Texas MD Anderson Cancer Center explores the complexities of managing brain metastases, a serious complication of advanced cancers. The study highlights the increasing complexity of treatment options due to advancements in local and systemic therapies. Traditionally, surgery and radiation have been the mainstays of treatment, but emerging clinical data suggests promising results with novel systemic treatments such as immunotherapy and targeted therapies. The study emphasizes the need for a more inclusive approach in clinical trials and provides a comprehensive overview of the current state and future directions in managing brain metastases. [Extracted from the article]

: Copyright of Immunotherapy Weekly is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Cancer Weekly; 7/9/2024, p497-497, 1p

مصطلحات موضوعية: NON-small-cell lung carcinoma, BRAIN metastasis, STEREOTACTIC radiosurgery, BRAIN cancer, METASTASIS

مستخلص: A study conducted at the University of Virginia Health System examined the use of stereotactic radiosurgery (SRS) in the management of non-small cell lung cancer (NSCLC) brain metastases. The study utilized a national quality registry and found that patients with NSCLC brain metastases who underwent SRS had favorable overall survival compared to previous randomized controlled trials. The study also identified risk factors for mortality and progression outcomes, including the number of lesions present and the control of the primary tumor. The research highlights the importance of SRS in the treatment of NSCLC brain metastases and provides valuable insights for clinicians. [Extracted from the article]

: Copyright of Cancer Weekly is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Medical Devices & Surgical Technology Week; 7/8/2024, p1015-1015, 1p

مصطلحات موضوعية: BRAIN metastasis, STEREOTACTIC radiosurgery, RADIOSURGERY, ONCOLOGY, RADIATION, SURGICAL technology

مستخلص: A recent study conducted in Aarau, Switzerland explored the feasibility of preoperative radiosurgery (SRS) for brain metastases (BM). The study aimed to achieve cavity local control and reduce leptomeningeal relapse (LMD) without additional radionecrosis compared to postoperative SRS. Thirteen patients were recruited, and 12 of them received preoperative radiosurgery and metastasectomy. The primary endpoint of delivering preoperative SRS in all patients prior to gross tumor resection was not met. However, the study found that linac-based preoperative SRS was feasible and safe in patients with large brain metastases without raised intracranial pressure. [Extracted from the article]

: Copyright of Medical Devices & Surgical Technology Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Medical Devices & Surgical Technology Week; 7/8/2024, p1261-1261, 1p

مصطلحات موضوعية: STEREOTACTIC radiosurgery, BRAIN metastasis, EMERGENCY room visits, TREATMENT effectiveness, LASERS, SURGICAL technology

مستخلص: A recent study conducted by researchers at Brown University in Providence, Rhode Island, explored the use of laser interstitial thermal therapy followed by consolidation stereotactic radiosurgery (LITT-cSRS) in patients with newly diagnosed brain metastasis. The study included ten cancer patients with newly diagnosed brain masses who underwent stereotactic needle biopsy and LITT followed by cSRS. The results showed promising outcomes, with no complications or readmissions within 90 days. The researchers concluded that LITT-cSRS appears to be safe and effective, providing a foundation for future studies in this area. [Extracted from the article]

: Copyright of Medical Devices & Surgical Technology Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Medical Devices & Surgical Technology Week; 7/8/2024, p2411-2411, 1p

مصطلحات موضوعية: STEREOTACTIC radiosurgery, BRAIN metastasis, BRAIN research, STATE universities & colleges, SURGICAL technology, REPORTERS & reporting

الشركة/الكيان: OHIO State University

مستخلص: A study conducted at Ohio State University evaluated the safety and feasibility of using stereotactic radiosurgery (SRS) as a treatment for patients with 15 or more brain metastases (BM). The study found that SRS was safe and had favorable cognitive outcomes, with comparable survival outcomes to whole brain radiation therapy (WBRT). Treatment-naive patients had a median survival of over 6 months, making them suitable candidates for SRS. The study suggests that further research should be conducted to compare SRS with other treatment approaches for these patients. [Extracted from the article]

: Copyright of Medical Devices & Surgical Technology Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Pain & Central Nervous System Week; 7/5/2024, p273-273, 1p

مصطلحات موضوعية: BRAIN metastasis, PUBLIC hospitals, UNIVERSITY hospitals, STEREOTACTIC radiosurgery, SURGERY, RADIATION

مستخلص: A recent study conducted at the National University Hospital in Singapore explored the feasibility of using Gamma Knife surgery (GKS) as a treatment option for patients with 20 or more brain metastases (BM), without the use of adjunct whole brain radiation treatment (WBRT). The researchers found that GKS was a reasonable treatment option for selected patients, with a median survival time of 9 months. The study also found that the number of BM was not significantly related to the development of distant recurrences (DR), but rather factors such as age and clinical condition at the time of GKS. The researchers concluded that it is better to manage post-GKS intracranial disease progression once it occurs, rather than trying to prevent it with adjunct WBRT. [Extracted from the article]

: Copyright of Pain & Central Nervous System Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Drug Week; 7/5/2024, p1308-1308, 1p

مصطلحات موضوعية: HIPPO signaling pathway, BRAIN metastasis, STEREOTACTIC radiosurgery, RESEARCH personnel, LUNGS, PROGRAMMED death-ligand 1

مستخلص: A recent report from researchers at the University of Caen Normandy in France discusses the poor prognosis for patients with non-small cell lung cancer (NSCLC), which often leads to brain metastases (BMs). The report highlights the challenges of treating BMs, particularly the issue of radioresistance (RR) that prevents the effectiveness of radiotherapy (RT). The researchers suggest that inhibiting the Hippo pathway, specifically the effector yes-associated protein-1, may be a potential strategy to prevent RR and improve outcomes for patients with BMs originating from lung cancer. This research has been peer-reviewed and published in the International Journal of Oncology. [Extracted from the article]

: Copyright of Drug Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Cancer Weekly; 7/2/2024, p1340-1340, 1p

مصطلحات موضوعية: CLINICAL trials, STEREOTACTIC radiosurgery, BRAIN metastasis, RADIOTHERAPY, LUNG cancer, SMALL cell lung cancer, MYOCARDIAL infarction, MEDICAL sciences

مستخلص: This document provides information about a clinical trial conducted by the Cancer Institute and Hospital, Chinese Academy of Medical Sciences. The trial aims to compare the effectiveness of two treatment approaches for brain metastases in patients with small cell lung cancer. The active comparator group will receive whole-brain radiation therapy, while the experimental group will receive local treatment for brain metastases. The trial is currently recruiting participants, with an estimated completion date of February 28, 2028. [Extracted from the article]

: Copyright of Cancer Weekly is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المصدر: Drug Week; 6/21/2024, p367-367, 1p

مصطلحات موضوعية: RADIOSURGERY, STEREOTACTIC radiosurgery, BRAIN metastasis, INTRACRANIAL hemorrhage, IMMUNE checkpoint inhibitors

مستخلص: A study conducted at the Mayo Clinic in Rochester, Minnesota analyzed the risk of hemorrhage in patients with melanoma brain metastases after undergoing Gamma Knife radiosurgery (GKRS). The study found that 13% of lesions experienced definite or possible lesional hemorrhages, with 4% of lesions experiencing grade 3 hemorrhages. Surgical intervention was required in 2% of cases. The study also found that antiplatelet agents and immune checkpoint inhibitors were associated with improved overall survival, while definite/possible hemorrhage and whole-brain radiotherapy were associated with shorter overall survival. The cumulative risk of lesional hemorrhage was 17%-20% at 36 months from GKRS, with the majority of cases occurring within the first year. [Extracted from the article]

: Copyright of Drug Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)