مورد إلكتروني
Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers.
| العنوان: | Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers. |
|---|---|
| المؤلفون: | Nakayama, Tsuguhisa |
| بيانات النشر: | eScholarship, University of California 2021-09-28 |
| تفاصيل مُضافة: | Nakayama, Tsuguhisa Lee, Ivan T Jiang, Sizun Matter, Matthias S Yan, Carol H Overdevest, Jonathan B Wu, Chien-Ting Goltsev, Yury Shih, Liang-Chun Liao, Chun-Kang Zhu, Bokai Bai, Yunhao Lidsky, Peter Xiao, Yinghong Zarabanda, David Yang, Angela Easwaran, Meena Schürch, Christian M Chu, Pauline Chen, Han Stalder, Anna K McIlwain, David R Borchard, Nicole A Gall, Phil A Dholakia, Sachi S Le, Wei Xu, Le Tai, Chih-Jaan Yeh, Te-Huei Erickson-Direnzo, Elizabeth Duran, Jason M Mertz, Kirsten D Hwang, Peter H Haslbauer, Jasmin D Jackson, Peter K Menter, Thomas Andino, Raul Canoll, Peter D DeConde, Adam S Patel, Zara M Tzankov, Alexandar Nolan, Garry P Nayak, Jayakar V |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Understanding viral tropism is an essential step towards reducing SARS-CoV-2 transmission, decreasing mortality from COVID-19, and limiting opportunities for mutant strains to arise. Currently, little is known about the extent to which distinct tissue sites in the human head & neck region and proximal respiratory tract selectively permit SARS-CoV-2 infection and replication. In this translational study, we discover key variabilities in the expression of ACE2 and TMPRSS2, essential SARS-CoV-2 entry factors, among the mucosal tissues of the human proximal airways. We show that SARS-CoV-2 infection is present in all examined head & neck tissues, with a notable tropism for the nasal cavity and tracheal mucosa. Finally, we uncover an association between smoking and higher SARS-CoV-2 viral infection in the human proximal airway, which may explain the increased susceptibility of smokers to developing severe COVID-19. This is at least partially explained by differences in IFN-β1 levels between smokers and non-smokers. |
| مصطلحات الفهرس: | Clinical Research, Tobacco, Infectious Diseases, Pneumonia, Emerging Infectious Diseases, Tobacco Smoke and Health, Biodefense, Vaccine Related, Lung, Dental/Oral and Craniofacial Disease, Prevention, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Infection, Respiratory, publication |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf |
| أرقام أخرى: | CDLER oai:escholarship.org/ark:/13030/qt09b2v7q5 qt09b2v7q5 https://escholarship.org/uc/item/09b2v7q5Test https://escholarship.orgTest/ 1277075690 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1277075690 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |