مورد إلكتروني
Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.
| العنوان: | Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States. |
|---|---|
| المؤلفون: | Kim, Jong Wook |
| المصدر: | Cell systems; vol 5, iss 2, 105-118.e9; 2405-4712 |
| بيانات النشر: | eScholarship, University of California 2017-08-01 |
| تفاصيل مُضافة: | Kim, Jong Wook Abudayyeh, Omar O Yeerna, Huwate Yeang, Chen-Hsiang Stewart, Michelle Jenkins, Russell W Kitajima, Shunsuke Konieczkowski, David J Medetgul-Ernar, Kate Cavazos, Taylor Mah, Clarence Ting, Stephanie Van Allen, Eliezer M Cohen, Ofir Mcdermott, John Damato, Emily Aguirre, Andrew J Liang, Jonathan Liberzon, Arthur Alexe, Gabriella Doench, John Ghandi, Mahmoud Vazquez, Francisca Weir, Barbara A Tsherniak, Aviad Subramanian, Aravind Meneses-Cime, Karina Park, Jason Clemons, Paul Garraway, Levi A Thomas, David Boehm, Jesse S Barbie, David A Hahn, William C Mesirov, Jill P Tamayo, Pablo |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The systematic sequencing of the cancer genome has led to the identification of numerous genetic alterations in cancer. However, a deeper understanding of the functional consequences of these alterations is necessary to guide appropriate therapeutic strategies. Here, we describe Onco-GPS (OncoGenic Positioning System), a data-driven analysis framework to organize individual tumor samples with shared oncogenic alterations onto a reference map defined by their underlying cellular states. We applied the methodology to the RAS pathway and identified nine distinct components that reflect transcriptional activities downstream of RAS and defined several functional states associated with patterns of transcriptional component activation that associates with genomic hallmarks and response to genetic and pharmacological perturbations. These results show that the Onco-GPS is an effective approach to explore the complex landscape of oncogenic cellular states across cancers, and an analytic framework to summarize knowledge, establish relationships, and generate more effective disease models for research or as part of individualized precision medicine paradigms. |
| مصطلحات الفهرس: | Cell Line, Tumor, Humans, Neoplasms, Gene Expression Profiling, MAP Kinase Signaling System, Gene Expression Regulation, Neoplastic, Genes, ras, Genome, Biomarkers, Precision Medicine, Bayesian nomogram, cellular states, drug sensitivity, genetic dependency, inferential model, matrix factorization, oncoGPS, oncogenic pathway, precision medicine, transcriptional signatures, Biotechnology, Cancer, Human Genome, Genetics, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Biochemistry and Cell Biology, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Cell systems vol 5, iss 2, 105-118.e9 2405-4712 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt5bd275sf qt5bd275sf https://escholarship.org/uc/item/5bd275sfTest https://escholarship.orgTest/ 1391612848 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1391612848 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |