مورد إلكتروني
Multivariate alterations in insula - Medial prefrontal cortex linked to genetics in 12q24 in schizophrenia.
| العنوان: | Multivariate alterations in insula - Medial prefrontal cortex linked to genetics in 12q24 in schizophrenia. |
|---|---|
| المؤلفون: | Jiang, Wenhao |
| بيانات النشر: | eScholarship, University of California 2021-12-01 |
| تفاصيل مُضافة: | Jiang, Wenhao Rootes-Murdy, Kelly Chen, Jiayu Bizzozero, Nora I Perrone Calhoun, Vince D van Erp, Theo GM Ehrlich, Stefan Agartz, Ingrid Jönsson, Erik G Andreassen, Ole A Wang, Lei Pearlson, Godfrey D Glahn, David C Hong, Elliot Liu, Jingyu Turner, Jessica A |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The direct effect of genetic variations on clinical phenotypes within schizophrenia (SZ) remains elusive. We examined the previously identified association of reduced gray matter concentration in the insula - medial prefrontal cortex and a quantitative trait locus located in 12q24 in a SZ dataset. The main analysis was performed on 1461 SNPs and 830 participants. The highest contributing SNPs were localized in five genes including TMEM119, which encodes a microglial marker, that is associated with neuroinflammation and Alzheimer's disease. The gene set in 12q4 may partially explain brain alterations in SZ, but they may also relate to other psychiatric and developmental disorders. |
| مصطلحات الفهرس: | Brain, Prefrontal Cortex, Humans, Magnetic Resonance Imaging, Cognition, Schizophrenia, Gray Matter, Insula, QTL, Genetics, Acquired Cognitive Impairment, Serious Mental Illness, Mental Health, Neurosciences, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Mental health, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, publication |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt2pz405tv qt2pz405tv https://escholarship.org/uc/item/2pz405tvTest https://escholarship.orgTest/ 1391591554 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1391591554 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |