مورد إلكتروني
Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae
| العنوان: | Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae |
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| بيانات النشر: | MDPI 2013 |
| تفاصيل مُضافة: | Universidade de Santiago de Compostela. Departamento de Farmacoloxía Universidade de Santiago de Compostela. Departamento de Fisioloxía Rubiolo Gaytán, Juan Andrés Ternon, Eva López Alonso, Henar Thomas, Olivier P. Vega Lisi, Félix Víctor Rodríguez Vieytes, María Mercedes Botana López, Luis Miguel |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | In this paper, we show the effect of crambescidin-816, -800, and -830 on Saccharomyces cerevisiae viability. We determined that, of the three molecules tested, crambescidin-816 was the most potent. Based on this result, we continued by determining the effect of crambescidin-816 on the cell cycle of this yeast. The compound induced cell cycle arrest in G2/M followed by an increase in cell DNA content and size. When the type of cell death was analyzed, we observed that crambescidin-816 induced apoptosis. The antifungal effect indicates that crambescidins, and mostly crambescidin-816, could serve as a lead compound to fight fungal infections |
| مصطلحات الفهرس: | Crambescidine-816, Antifungal, Cell cycle arrest, Apoptosis, journal article |
| URL: | info:eu-repo/grantAgreement/EC/FP7/265896 info:eu-repo/grantAgreement/EC/FP7/265409 info:eu-repo/grantAgreement/EC/FP7/262649 info:eu-repo/grantAgreement/EC/FP7/315285 info:eu-repo/grantAgreement/EC/FP7/312184 info:eu-repo/grantAgreement/MICINN/Plan Nacional de I+D+i 2008-2011/AGL2009-13581-C02-01/ES/Evaluacion De Los Riesgos De Salud Publica Debidos A Toxinas Marinas De Aguas Templadas En Las Costas Europeas Y Del Efecto Sinergico Con Otras Toxinas Habituales En Estas Latitudes. Subproyecto 2 |
| الإتاحة: | Open access content. Open access content http://creativecommons.org/licenses/by/3.0Test open access © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0Test/) |
| ملاحظة: | English |
| أرقام أخرى: | ESUSC oai:minerva.usc.es:10347/23606 Rubiolo, J.A.; Ternon, E.; López-Alonso, H.; Thomas, O.P.; Vega, F.V.; Vieytes, M.R.; Botana, L.M. Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae. Mar. Drugs 2013, 11, 4419-4434 10.3390/md11114419 1660-3397 1400993532 |
| المصدر المساهم: | UNIVERSIDADE DE SANTIAGO DE COMPOSTELA From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1400993532 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |