مورد إلكتروني
Semiquantitative Imaging Biomarkers of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.
| العنوان: | Semiquantitative Imaging Biomarkers of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium. |
|---|---|
| المؤلفون: | Collins, Jamie E |
| المصدر: | Arthritis & rheumatology (Hoboken, N.J.); vol 68, iss 10, 2422-2431; 2326-5191 |
| بيانات النشر: | eScholarship, University of California 2016-10-01 |
| تفاصيل مُضافة: | Collins, Jamie E Losina, Elena Nevitt, Michael C Roemer, Frank W Guermazi, Ali Lynch, John A Katz, Jeffrey N Kent Kwoh, C Kraus, Virginia B Hunter, David J |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | ObjectiveTo determine the association between changes in semiquantitative magnetic resonance imaging (MRI) biomarkers over 24 months and radiographic and pain progression over 48 months in knees with mild-to-moderate osteoarthritis (OA).MethodsWe undertook a nested case-control study as part of the Foundation for the National Institutes of Health Biomarkers Consortium Project. We used multivariable logistic regression models to examine the association between change over 24 months in semiquantitative MRI markers and radiographic and pain progression in knee OA. MRIs were read according to the MRI OA Knee Score system. We focused on changes in cartilage, osteophytes, meniscus, bone marrow lesions, Hoffa-synovitis, and effusion-synovitis.ResultsThe most parsimonious model included changes in cartilage thickness and surface area, effusion-synovitis, Hoffa-synovitis, and meniscal morphology (C statistic 0.740). Compared with no worsening, worsening in cartilage thickness in ≥3 subregions was associated with 2.8-fold (95% confidence interval [95% CI] 1.3-5.9) greater odds of being a case, and worsening in cartilage surface area in ≥3 subregions was associated with 2.4-fold (95% CI 1.3-4.4) greater odds of being a case. Worsening of meniscal morphology in any region was associated with 2.2-fold (95% CI 1.3-3.8) greater odds of being a case. Worsening effusion-synovitis and Hoffa-synovitis were also associated with a greater odds of being a case (odds ratios 2.7 and 2.0, respectively).ConclusionTwenty-four-month changes in cartilage thickness, cartilage surface area, effusion-synovitis, Hoffa-synovitis, and meniscal morphology were independently associated with OA progression, suggesting that these factors may serve as efficacy biomarkers in clinical trials of disease-modifying interventions for knee OA. |
| مصطلحات الفهرس: | Cartilage, Articular, Menisci, Tibial, Knee Joint, Bone Marrow, Humans, Arthralgia, Osteoarthritis, Knee, Synovitis, Bone Marrow Diseases, Disease Progression, Magnetic Resonance Imaging, Radiography, Organ Size, Multivariate Analysis, Logistic Models, Case-Control Studies, Aged, Middle Aged, Female, Male, Osteophyte, Tibial Meniscus Injuries, Chronic Pain, Arthritis, Aging, Pain Research, Musculoskeletal, Clinical Sciences, Immunology, Public Health and Health Services, Arthritis & Rheumatology, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Arthritis & rheumatology (Hoboken, N.J.) vol 68, iss 10, 2422-2431 2326-5191 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt14n7r761 qt14n7r761 https://escholarship.org/uc/item/14n7r761Test https://escholarship.orgTest/ 1378687508 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1378687508 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |