رسالة جامعية
Evaluacija uticaja terapije insulinskim analozima na parametre oksidativnog stresa kod bolesnika sa dijabetesom melitusom tip 1 ; Evaluation of the effect of the therapy with insulin analogues on oxidative stress in patients with type 1 diabetes mellitus
| العنوان: | Evaluacija uticaja terapije insulinskim analozima na parametre oksidativnog stresa kod bolesnika sa dijabetesom melitusom tip 1 ; Evaluation of the effect of the therapy with insulin analogues on oxidative stress in patients with type 1 diabetes mellitus |
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| المؤلفون: | Radenković, Saša P. |
| المساهمون: | Kocić, Radivoj, Ilić, Stevan, Pešić, Milica, Stojanović, Ivana, Lalić, Nebojša M. |
| المصدر: | Универзитет у Нишу |
| بيانات النشر: | Универзитет у Нишу, Медицински факултет |
| سنة النشر: | 2020 |
| المجموعة: | NaRDuS (National Repository of Dissertations in Serbia) / Nacionalni Repozitorijum Disertacija u Srbiji |
| مصطلحات موضوعية: | Dijabetes melitus tip 1, glikemijska kontrola, hipoglikemija, insulin aspart, insulin glargin, oksidativni stres, malondialdehid, nitrati i nitriti, ksantin oksidaza, antioksidantni enzimi, diabetes mellitus type 1, glycemic control, hypoglycemia, insulin glargine, oxidative stress, malondialdehyde, nitrite/nitrate, xanthine oxidase, antioxidant enzymes |
| الوصف: | Significance of Type 1 diabetes mellitus is in it’s acute and chronic complications. Big studies demonstrated that microvascular complications of diabetes can be avoided or delayed if blood glucose levels are maintained as close to the normal range as possible. Diabetic state is closely related with increase in oxidative stress and studies suggest that ROS are important in pathogenesis of diabetic vascular dysfunction and that pathways of development of diabetic complications are closely connected with oxidative stress. High blood glucose leads to increase generation of ROS in mitochondria. Intensive insulin therapy is the cornerstone for tight glycemic control in type 1 diabetic patients. Basic difficulties in achieving glycemic goals are maintenance of near-euglycemia and avoidance of hypoglycemia and significant weight gain. Insulin analogues have improved pharmacokinetic properties that allow better control of both fasting and postprandial glycaemia. Aim of this work was to analyze efficacy of intensive insulin therapy with human insulin analogues (aspart and glargine) with analysis of glycoregulation (HbA1c, fasting blood glucose, postprandial glucose and glucose variability), safety with analysis of hypoglycemia, body weight and quality of life, and analysis of markers of oxidative stress. In this prospective clinical trial we analyzed clinical and laboratory parameters in Type 1 diabetic patients. Study included 49 patients with T1DM and previous therapy with human insulin for at least one year, currently on IIT with four daily doses of human insulin. For the first three months rapid acting insulin analogue (insulin aspart) was introduced instead of regular human insulin, and then in the next three months patients were treated with basal insulin analogue (insulin glargine) instead of intermediate acting human insulin. The mean HbA1c level fell after introduction of insulin analogues therapy. There was small but no significant decline in HbA1c level during 3 months of therapy with insulin aspart and HbA1c ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | application/pdf |
| اللغة: | Serbian |
| العلاقة: | https://nardus.mpn.gov.rs/handle/123456789/3937Test; http://eteze.ni.ac.rs/application/showtheses?thesesId=1450Test; https://fedorani.ni.ac.rs/fedora/get/o:895/bdef:Content/downloadTest; http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1024842733Test; https://nardus.mpn.gov.rs/bitstream/id/52915/Disertacija.pdfTest; http://nardus.mpn.gov.rs/bitstream/id/52915/Disertacija.pdfTest; https://hdl.handle.net/21.15107/rcub_nardus_3937Test |
| الإتاحة: | https://nardus.mpn.gov.rs/handle/123456789/3937Test http://eteze.ni.ac.rs/application/showtheses?thesesId=1450Test https://fedorani.ni.ac.rs/fedora/get/o:895/bdef:Content/downloadTest http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1024842733Test https://nardus.mpn.gov.rs/bitstream/id/52915/Disertacija.pdfTest http://nardus.mpn.gov.rs/bitstream/id/52915/Disertacija.pdfTest https://hdl.handle.net/21.15107/rcub_nardus_3937Test |
| حقوق: | openAccess ; https://creativecommons.org/licenses/by-nc/4.0Test/ ; BY-NC |
| رقم الانضمام: | edsbas.F7C85F4E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |