رسالة جامعية
Biomarkers in pheochromocytomas and paragangliomas
| العنوان: | Biomarkers in pheochromocytomas and paragangliomas |
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| المؤلفون: | Leijon, Helena |
| المساهمون: | Kujala, Paula, University of Helsinki, Faculty of Medicine, Department of Pathology, Doctoral Programme in Biomedicin, Helsingin yliopisto, lääketieteellinen tiedekunta, Biolääketieteellinen tohtoriohjelma, Helsingfors universitet, medicinska fakulteten, Doktorandprogrammet i biomedicin, Arola, Johanna, Haglund, Caj, Salmenkivi, Kaisa |
| بيانات النشر: | Helsingin yliopisto Helsingfors universitet University of Helsinki |
| سنة النشر: | 2018 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | Lääketiede |
| الوصف: | Pheochromocytomas (PHEOs) derived from adrenal medulla and paragangliomas (PGLs) from sympathetic or parasympathetic paraganglia are rare neuroendocrine tumors. Incidence of PHEOs and PGLs is between 0.4–9.5 cases per one million people per year. In Finland about 10–15 PHEOs are diagnosed per year, but the incidence is rising. PHEOs and sympathetic PGLs can secrete catecholamines, often in bouts, which makes the symptoms associated with these tumors very diverse, with high blood pressure being the leading symptom. During recent years, knowledge of the variable genetic background and pathogenesis of PGLs and PHEOs has increased, and about 30-40% of these tumors are known to be hereditary. However, prognosis and aggressiveness of an individual tumor cannot be unequivocally predicted histologically or with any biomarkers. The aim of this thesis was to find biomarkers in PHEOs and PGLs for diagnostic, prognostic, and predictive purposes. The study cohort consisted of 153 consecutive PHEOs or PGLs operated from 147 patients during the years 1973–2009 at Helsinki University Hospital. Tissue microarray blocks were constructed for immunohistochemistry studies. Matrix-assisted laser desorption/ionization time of flight mass spectrometric profiling of 16 tissue samples was used to analyze N-glycan structures in eight metastasized and eight nonmetastasized tumors. In addition, five thyroid PGLs originating from the population-based European-American-Head-and-Neck-Paraganglioma-Registry (European-American-HNPGL-Registry, Freiburg, Germany) were investigated. Metastasized PHEOs and PGLs expressed significantly more intracytoplasmic human antigen R (HuR) protein immunohistochemically than nonmetastasized tumors. The metastatic potential was also associated with higher proliferation and tumor necrosis. Five somatostatin receptors (SSTR1–5) showed individual and varying SSTR profiles in PHEOs and PGLs. The most abundant SSTRs were SSTR2 and SSTR3. Between metastatic PHEOs and PGLs the SSTR2 expression varied – all PGLs were ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-951-51-4750-9 978-951-51-4751-6 951-51-4750-6 951-51-4751-4 |
| العلاقة: | URN:ISBN:978-951-51-4750-9; Helsinki: Unigrafia, 2018; http://hdl.handle.net/10138/266764Test; URN:ISBN:978-951-51-4751-6 |
| الإتاحة: | http://hdl.handle.net/10138/266764Test |
| حقوق: | Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. ; This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. ; Publikationen är skyddad av upphovsrätten. Den får läsas och skrivas ut för personligt bruk. Användning i kommersiellt syfte är förbjuden. |
| رقم الانضمام: | edsbas.D973D3C0 |
| قاعدة البيانات: | BASE |
| ردمك: | 9789515147509 9789515147516 9515147506 9515147514 |
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