| الوصف: |
The focus for this thesis is on two major determinants of health and wellbeing in older people, namely subjective sleep disturbance and cognition. Data were drawn from the H70 Birth Cohort Studies, comprising representative samples of older people living in Gothenburg, Sweden. In Study I, we examined birth cohort differences regarding prevalence of insomnia (i.e., difficulties initiating sleep, maintaining sleep, and early morning awakenings) in two cohorts of 70-year-olds born three decades apart and followed over nine years. The later-born cohort showed lower prevalence ofinsomnia atage 70 compared with theearlier-born cohort. However, the prevalence of insomnia increased with age in the later-born but was stable in the earlier-born cohort. In Study II, we investigated cognitive status and change measured by the Mini-Mental State Examination (MMSE) among 97-year-olds followed over three years. We found that MMSE scores at baseline were related to dementia at baseline, but not to development of dementia during follow-up. Those who died during the three-year follow-up had lower MMSE scores than those who survived. Furthermore, participants with more education had higher MMSE scores, but there was no association between education and cognitive change. In Study III, which was a multicenter study, including additional samples from Stockholm and Finland, we investigated whether poor sleep in midlife and late life was associated with an elevated risk of developing dementia in late life. We found that midlife insomnia and late-life terminal insomnia (i.e., early morning awakenings) and long sleep duration were associated with a higher late-life dementia risk. In Study IV, we investigated if poor sleep was related to cerebrospinal fluid (CSF) markers of Alzheimer’s disease (AD) and if these associations were moderated by possession of the apolipoprotein (APOE) ε4 allele. We found that reduced sleep, increased sleep and taking sleep medication were associated with markers of amyloid plaque accumulation (amyloid β 42/40 ... |
| العلاقة: |
Doctoral Dissertation; 1. Skoog, J., Jonsson, H., Sigstrom, R., Ostling, S., Falk, H., Waern, M., Thorvaldsson, V., Skoog, I., & Johansson, B. (2019). Do later-born birth cohorts of septuagenarians sleep better? A prospective population-based study of two birth cohorts of 70-year-olds. Sleep, 42(1-8). ::doi:: 10.1093/sleep/zsy204; 2. Skoog, J., Backman, K., Ribbe, M., Falk, H., Gudmundsson, P., Thorvaldsson, V., Borjesson‐Hanson, A., Ostling, S., Johansson, B., & Skoog, I. (2017). A longitudinal study of the Mini‐Mental State Examination in late nonagenarians and its relationship with dementia, mortality, and education. Journal of the American Geriatrics Society, 65(6), 1296–1300. ::doi:: 10.1111/jgs.14871; 3. Sindi, S., Kåreholt, I., Johansson, L., Skoog, J., Sjöberg, L., Wang, H. X., Johansson, B., Fratiglioni, L., Soininen, H., & Solomon, A. (2018). Sleep disturbances and dementia risk: A multicenter study. Alzheimer's & Dementia, 14(10), 1235–1242. ::doi:: 10.1016/j.jalz.2018.05.012; 4. Skoog, J., Zetterberg, H., Blennow, K., Kern, S., Johansson, B., Skoog, I. & Thorvaldsson, V. (2020). A populationbased study on sleep and CSF-markers of Alzheimer's disease: The influence of the APOE ε4 allele. Manuscript submitted for publication.; http://hdl.handle.net/2077/66865Test |
