رسالة جامعية
The impacts of miRNAs on viral replication and host immune responses in enterovirus 71 infection
| العنوان: | The impacts of miRNAs on viral replication and host immune responses in enterovirus 71 infection |
|---|---|
| العنوان البديل: | 微核醣核酸於71型腸病毒感染中對病毒複製和宿主免疫反應的影響 |
| المؤلفون: | Bing-Ching Ho, 何炳慶 |
| مرشدي الرسالة: | Chun-Nan Lee, 李君男 |
| سنة النشر: | 2011 |
| المجموعة: | National Digital Library of Theses and Dissertations in Taiwan |
| الوصف: | 99 Virus processes complicated interactions with the host in virus infection. Virus relay on the host translation machinery to complete their life cycles and cause viral pathogenesis. In contrast, host utilizes immune system to eliminate virus spread. MicroRNAs (miRNAs) are a recently discovered class of small non-protein-coding RNAs that may act via endogenous RNA interference to govern a wide range of biological functions including host-virus interaction. In this thesis, we identified two miRNAs, miR-141 and miR-146a, which play significant roles in virus-host interactions. miR-141, the most up-regulated miRNA, targets the cap-dependent translation initiation factor, eIF4E, for shutoff of host protein synthesis and promotes the switch from cap-dependent to cap-independent translation. miR-146a, the other up-regulated miRNA, suppressed two interferon-associated proteins, TRAF6 and IRAK1, through pairing to their 3’ untranslated regions. It was documented that suppression of TRAF6 and IRAK1 resulted in attenuation of host interferon responses. We hypothesized that EV71 might shutoff of host protein synthesis and escape host antiviral activity through regulation of the two miRNAs, and created a beneficial environment for its replication. |
| Original Identifier: | 099NTU05108002 |
| نوع الوثيقة: | 學位論文 ; thesis |
| وصف الملف: | 150 |
| الإتاحة: | http://ndltd.ncl.edu.tw/handle/57640322216184157578Test |
| رقم الانضمام: | edsndl.TW.099NTU05108002 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| الوصف غير متاح. |