دورية أكاديمية
Placental Size Is Associated with Mental Health in Children and Adolescents
| العنوان: | Placental Size Is Associated with Mental Health in Children and Adolescents |
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| المؤلفون: | Khalife, Natasha, Glover, Vivette, Hartikainen, Anna-Liisa, Taanila, Anja, Ebeling, Hanna, Jarvelin, Marjo-Riitta, Rodriguez, Alina |
| بيانات النشر: | Mittuniversitetet, Institutionen för samhällsvetenskap; Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, London, England; Univ London Imperial Coll Sci Technol & Med, Inst Reprod & Dev Biol, London, England; Univ Oulu, Inst Clin Med, Oulu, Finland; Univ Oulu, Inst Hlth Sci, Oulu, Finland; Oulu Univ Hosp, Clin Child Psychiat, Oulu, Finland, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | DiVA Archive at Upsalla University |
| Original Material: | ISI:000306354700058 Scopus 84863633083 |
| مصطلحات موضوعية: | adolescent, article, attention deficit disorder, birth weight, child, child behavior, child health, cohort analysis, controlled study, demography, disease association, female, Finland, gestational age, human, major clinical study, male, mental disease, mental health, placenta weight, prospective study, school child |
| الوصف: | Background: The role of the placenta in fetal programming has been recognized as a highly significant, yet often neglected area of study. We investigated placental size in relation to psychopathology, in particular attention deficit hyperactivity disorder (ADHD) symptoms, in children at 8 years of age, and later as adolescents at 16 years. Methodology/Principal Findings: Prospective data were obtained from The Northern Finland Birth Cohort (NFBC) 1986. Placental weight, surface area and birth weight were measured according to standard procedures, within 30 minutes after birth. ADHD symptoms, probable psychiatric disturbance, antisocial disorder and neurotic disorder were assessed at 8 years (n = 8101), and ADHD symptoms were assessed again at 16 years (n = 6607), by teachers and parents respectively. We used logistic regression analyses to investigate the association between placental size and mental health outcomes, and controlled for gestational age, birth weight, socio-demographic factors and medical factors, during gestation. There were significant positive associations between placental size (weight, surface area and placental-to-birth-weight ratio) and mental health problems in boys at 8 and 16 years of age. Increased placental weight was linked with overall probable psychiatric disturbance (at 8y, OR = 1.14 [95% CI = 1.04-1.25]), antisocial behavior (at 8 y, OR = 1.14 [95% CI = 1.03-1.27]) and ADHD symptoms (inattention-hyperactivity at 16y, OR = 1.19 [95% CI = 1.02-1.38]). No significant associations were detected among girls. Conclusions/Significance: Compensatory placental growth may occur in response to prenatal insults. Such overgrowth may affect fetal development, including brain development, and ultimately contribute to psychopathology. |
| Original Identifier: | oai:DiVA.org:miun-17060 |
| نوع الوثيقة: | Article |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | PLoS ONE, 1932-6203, 2012, 7:7, s. Art. no. e40534- |
| DOI: | 10.1371/journal.pone.0040534 |
| الإتاحة: | http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-17060Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsndl.UPSALLA1.oai.DiVA.org.miun.17060 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| DOI: | 10.1371/journal.pone.0040534 |
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