رسالة جامعية
Pharmacokinetic and pharmacodynamic investigations of select natural products and nutraceuticals for human and veterinary health
| العنوان: | Pharmacokinetic and pharmacodynamic investigations of select natural products and nutraceuticals for human and veterinary health |
|---|---|
| المؤلفون: | Martinez, Stephanie |
| المساهمون: | Burczysnki, Frank (Pharmacy) Gong, Yuewen (Pharmacy) Beta, Trust (Food Science) Lefebvre, Jean (Laval University), Davies, Neal (Pharmacy) |
| بيانات النشر: | John Wiley & Sons, Ltd. Hindawi Publishing Corporation Wiled Periodicals, Inc. Medknow Publications Canadian Veterinary Medical Association WILEY-VCH Verlag CmbH & Co. John Wiley and Sons, Inc. |
| سنة النشر: | 2013 |
| المجموعة: | MSpace at the University of Manitoba |
| مصطلحات موضوعية: | Pharmacokinetics, Pharmacodynamics, Flavonoids, Natural products, Veterinary nutraceutical, Stilbenes, Methods of analysis, Chiral flavonoids, Humulus lupulus L, Content analysis |
| الوصف: | Natural products are teeming with potential therapeutic agents. One group of compounds, polyphenols, from plants, exhibit anti-cancer, anti-inflammatory and anti-oxidant activities. Four polyphenolic compounds and their enantiomers were investigated in this thesis; the stilbene, 3-methoxypterostilbene, a structural analog of resveratrol, and the chiral prenylflavonoids from hops (Humulus lupulus L.); 8-prenylnaringenin, 6-prenylnaringenin and isoxanthohumol. A high performance liquid chromatography method for 3-methoxypterostilbene and enantiospecific liquid chromatography-mass spectrometry assays for the three prenylflavonoids were developed and validated. The methods allowed for quantification of these four polyphenols in biological samples and plant-based materials. Content analysis studies of 3-methoxypterostilbene and the three prenylflavonoids in traditional Chinese medicinal plants and hops-containing nutraceuticals were carried out, respectively. The pharmacokinetics of these four compounds were delineated through intravenous and oral administration in rats. 3-Methoxypterostilbene demonstrated greater bioavailability in rats than reported values for resveratrol. Enantiomeric differences in disposition parameters were observed for the three prenylflavonoids along with differences between compounds despite only small structural differences. The in vitro pharmacodynamics of these four compounds were elucidated including anti-oxidant, anti-inflammatory, anti-diabetic and cytochrome P450 modulation activities. All four compounds demonstrated a range of bioactivities related to chronic diseases and potential drug-botanical interactions. Further studies of polyphenols, especially clinical studies, are needed along with enantiospecific study when applicable to continue delineating the importance of bioactivity, pharmacokinetics and safety. Natural products are further developed into nutraceuticals and sold over-the-counter for both human and veterinary use but are not currently required to demonstrate efficacy ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Martinez SE, Sayre CL, Davies NM. Analysis of 3-methoxypterostilbene in biological fluids by high-performance liquid chromatography: application to pre-clinical pharmacokinetics. Biomed Chromatogr. 2013 Jan;27(1):67-72.; Martinez SE, Sayre CL, Davies NM. Pharmacometrics of 3-methoxypterostilbeneL a component of traditional Chinese medicinal plants. Evid Based Complement Alternat Med. 2013;2013:261468.; Martinez SE, Lakowski TM, Davies NM. Enantiospecific analysis of 8-prenylnaringenin in biological fluids by liquid-chromatography-electrospray ionization mass spectrometry: application to preclinical pharmacokinetic investigations. Chirality. 2014 Aug;26(8):419-26.; Martinez SE, Davies NM. Stereospecific quantitation of 6-prenylnaringenin in commercially available H. lupulus-containing natural health products and dietary supplements. Res Pharm Sci .2015 May-Jun;10(3):182-91.; Martinez SE, Chen Y, Ho EA, Martinez SA, Davies NM. Pharmacological effects of a C-phycocyanin-based multicomponent nutraceutical in an in-vitro canine chondrocyte model of osteoarthritis. Can J Vet Res. 2015 Jul;79(3):241-9.; Martinez SE, Davies NM. Enantiospecific pharmacokinetics of isoxanthohumol and its metabolite 8-prenylnaringenin in the rat. Mol Nutr Food Res. 2015 Sep;59(9):1674-89.; Martinez SE, Davies NM, Reynolds JK. Toxicology and Safety of Flavonoids. In Davies NM & Yáñez JA (Eds.), Flavonoid Pharmacokinetics: Methods of Analysis, Pre-Clinical and Clinical Pharmacokinetics, Safety and Toxicology. New York: John Wiley and Sons, Inc., 2013.; Takemoto JK, Martinez SE, Davies NM. Analysis of Flavonoids through Chromatography. In Davies NM & Yáñez JA (Eds.), Flavonoid Pharmacokinetics: Methods of Analysis, Pre-Clinical and Clinical Pharmacokinetics, Safety and Toxicology. New York: John Wiley and Sons, Inc., 2013.; Yáñez JA, Sayre CL, Martinez SE, Davies NM. Chiral Methods of Flavonoid Analysis. In Davies NM & Yáñez JA (Eds.), Flavonoid Pharmacokinetics: Methods of Analysis, Pre-Clinical and Clinical Pharmacokinetics, Safety and Toxicology. New York: John Wiley and Sons, Inc., 2013.; Yáñez JA, Remsberg CM, Takemoto JK, Vega-Villa KR, Andrews PK, Sayre CL, Martinez SE, Davies NM. Polyphenols and Flavonoids: An Overview. In Davies NM & Yáñez JA (Eds.), Flavonoid Pharmacokinetics: Methods of Analysis, Pre-Clinical and Clinical Pharmacokinetics, Safety and Toxicology. New York: John Wiley and Sons, Inc., 2013.; http://hdl.handle.net/1993/31166Test |
| الإتاحة: | http://hdl.handle.net/1993/31166Test |
| حقوق: | open access |
| رقم الانضمام: | edsbas.72BC2710 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |