رسالة جامعية
Transmisibilidad e inocuidad de un candidato vacunal contra la tuberculosis bovina y evaluación de técnicas complementarias para el diagnóstico diferencial en la infección natural
| العنوان: | Transmisibilidad e inocuidad de un candidato vacunal contra la tuberculosis bovina y evaluación de técnicas complementarias para el diagnóstico diferencial en la infección natural |
|---|---|
| المؤلفون: | Ferrara Muñiz, Ximena |
| المساهمون: | Cataldi, Ángel Adrian, Eirin, Maria Emilia |
| بيانات النشر: | Facultad de Ciencias Veterinarias Universidad de Buenos Aires. Facultad de Ciencias Veterinarias |
| سنة النشر: | 2023 |
| المجموعة: | Repositorio Digital Institucional - Universidad de Buenos Aires (RDI UBA) |
| مصطلحات موضوعية: | Tuberculosis Bovina, Diagnostico, Vacuna, Bovine Tuberculosis, Diagnosis, Vaccine, Tuberculosis, Bovinos |
| الوصف: | Bovine tuberculosis (BTB), distributed worldwide, represents a problem for the livestock sector and a Public Health concern due to its zoonotic nature. The main causative agent is Mycobacterium bovis (M. bovis). BTB has a negative impact on the productivity and profitability of livestock farms, reducing production, due to sending infected animals to slaughter, confiscation in slaughterhouses and, because of the restrictions imposed on the commercialization and export of meat and dairy products, and their derivatives. In Argentina, although the National Control and Eradication Program (Law 128/2012, Senasa) reduced its prevalence based on ante-mortem diagnosis in herds and post-mortem epidemiological surveillance in slaughterhouses, due to its complexity, the disease continues to be a challenge. Vaccination, as a complementary intervention strategy, could reduce the impact of M. bovis infection in cattle, its main host. At present, there are no commercial vaccines, which must be developed in parallel to a differential diagnosis system that allows to distinguish between the vaccinated animal and the naturally infected one, without interfering with the official diagnostic test. In Argentina, the vaccine candidate M. bovis?mce2-phoP, deleted in two independent regions of the genome, the phoP gene (Mb0780) and the mce2AB genes (Mb0604-Mb0605), was obtained. M. bovis?mce2-phoP induced protection against challenge with a virulent strain of M. bovis in the murine model. In order to contribute to the characterization of the M. bovis?mce2-phoP candidate, the general objective of this work was to evaluate the safety and transmissibility of the M. bovis?mce2?phoP strain under experimental and natural infection conditions, and to develop a diagnostic system that allows to differentiate a vaccinated animal from an infected one. Different aspects of the M. bovis?mce2-phoP strain were studied when inoculated subcutaneously, such as its safety, its tropism, transmission, excretion, immunological aspects related to the diagnosis ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=avaposgra&cl=CL1&d=HWA_7156Test; http://repositoriouba.sisbi.uba.ar/gsdl/collect/avaposgra/index/assoc/HWA_7156.dir/7156.PDFTest |
| الإتاحة: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=avaposgra&cl=CL1&d=HWA_7156Test http://repositoriouba.sisbi.uba.ar/gsdl/collect/avaposgra/index/assoc/HWA_7156.dir/7156.PDFTest |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-ncnd/2.5/arTest/ |
| رقم الانضمام: | edsbas.D3918148 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |