رسالة جامعية
Fracture Rates in Adults with Neurofibromatosis Type 1
| العنوان: | Fracture Rates in Adults with Neurofibromatosis Type 1 |
|---|---|
| المؤلفون: | Azage, Meron Y., B.S. |
| بيانات النشر: | University of Cincinnati / OhioLINK, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | Ohiolink ETDs |
| Original Material: | http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337352142Test |
| مصطلحات موضوعية: | Genetics, Neurofibromatosis Type 1 (NF1), Adult, Fractures, Bone, Bone Mineral Density (BMD), Calcium |
| الوصف: | About 30-50% of patients with Neurofibromatosis Type 1 (NF1) have disease involving the skeletal system. Osteoporosis and low bone density are common findings; however increased rate of fractures in patients with NF1 has not yet been established in a well-designed clinical study. The purpose of this study is to compare the prevalence of fractures between adults with NF1 and unaffected controls including unaffected siblings/spouses of these patients. We hypothesized that the NF1 cohort will have fracture rates that are higher than unaffected controls. A retrospective questionnaire was administered to 38 adults with NF1 and 36 unaffected adults. Participants were asked to report fractures that occurred during their lifetime as well as in the past 10 years. The number of fractures, the bone location, age of participant when the fracture occurred, cause of fracture (such as trauma), time for healing, treatment and complications were assessed. We stratified fracture rates in cases and controls for age and sex, and statistically adjusted for other risk factors such as ethnicity, body mass index (BMI), tobacco use, menopause status, level of physical activity and dietary calcium intake. While adults with NF1 had higher 10 year fracture rate than controls, the difference did not reach statistical significant. Given the relatively small sample size in this study, collection of additional data is warranted. Improving our understanding of skeletal phenotype of NF1 may change clinical management, improve standard of care of patients and inform future drug trials for bone disease. |
| Original Identifier: | oai:etd.ohiolink.edu:ucin1337352142 |
| نوع الوثيقة: | text |
| اللغة: | English |
| الإتاحة: | http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337352142Test |
| حقوق: | unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| رقم الانضمام: | edsndl.OhioLink.oai.etd.ohiolink.edu.ucin1337352142 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| الوصف غير متاح. |