التفاصيل البيبلوغرافية
| العنوان: |
兩性偶氮苯樹枝狀衍生物的合成與可見光驅動順反異構化的探討 ; Synthesis of visible-light triggerable amphiphilic azobenzene dendrons toward liposome-based drug delivery. |
| المؤلفون: |
王吉東, Ji-Dong Wang |
| المساهمون: |
化學系所, 羅順原, Luo Shun-Yuan |
| سنة النشر: |
2018 |
| المجموعة: |
National Chung Hsing University Institutional Repository - NCHUIR / 國立中興大學 |
| مصطلحات موضوعية: |
偶氮苯, 光控, azobenzene, photoswitch |
| الوصف: |
In this thesis, we describe about drug delivery system and the uses of azobenzene amphiphilic moieties as a potential molecules toward liposome-based drug delivery. How to synthesize azobenzene amphiphilic structure is the point of this thesis and this article provides a reaction pathway to synthesize amphiphilic structure. In this article, we also test the photoswitch properties of the amphiphilic structure to determine the effectiveness of visible light radiation for azobenzene isomerization. ; Table of Content Abrreviation table. i Abstract. iii Table of Content. iv Table List. vi Figure List. vii Scheme List. viii Chapter 1. Introduction. 1 1. Drug Delivery System (DDS) . 1 2. Light Sensitive Liposome. 3 1. Photoisomerization………………. 5 2. Photocleavage….………….……. 6 3. Photocrosslinking/Photopolymerization ……………………. 7 3. Click Chemistry and its Application in Drug Delivery System. 8 4. Azobenzene and Its Preparation. 11 1. Azo coupling reaction. 12 2. Mills Reaction. 14 3. Wallach Reaction. 16 5. Azobenzene Photoswitch and Application. 17 6. Research Motivation…………………………………………………26 Chapter 2. Results and Discussion . 28 1. Retrosynthetic Analysis of Triazole. 28 2. Alkyne building block synthetic. 29 3. Azide building block synthesis. 31 4. Click reaction and deprotection reaction. 33 Chapter 3. Conclusion. 42 Chapter 4. Experimental Section. 43 1. General Information. 43 2. Experimental Procedure and Physical Data. 44 References. 51 Appendix. 54 |
| نوع الوثيقة: |
thesis |
| اللغة: |
English |
| العلاقة: |
http://hdl.handle.net/11455/97603Test |
| الإتاحة: |
http://hdl.handle.net/11455/97603Test |
| حقوق: |
restricted |
| رقم الانضمام: |
edsbas.C5239065 |
| قاعدة البيانات: |
BASE |
