مؤتمر
ST-segment elevation in the early repolarization syndrome, idiopathic ventricular fibrillation, and the Brugada syndrome: cellular and clinical linkage
| العنوان: | ST-segment elevation in the early repolarization syndrome, idiopathic ventricular fibrillation, and the Brugada syndrome: cellular and clinical linkage |
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| المؤلفون: | Shu, J, Zhu, TG, Yang, L, Cui, CC, Yan, GX |
| المساهمون: | Yan, GX (reprint author), Main Line Hlth Heart Ctr, Wynnewood, PA 19096 USA., Main Line Hlth Heart Ctr, Wynnewood, PA 19096 USA., Xian Jiaotong Univ, Hosp 1, Dept Cardiol, Xian 710061, Shaanxi, Peoples R China., Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China. |
| المصدر: | SCI |
| سنة النشر: | 2005 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | early repolarization syndrome, idiopathic ventricular fibrillation, Brugada syndrome, SUDDEN CARDIAC DEATH, ACUTE MYOCARDIAL-ISCHEMIA, SODIUM-CHANNEL BLOCKERS, BUNDLE-BRANCH BLOCK, INTRACELLULAR-RECORDINGS, T-WAVE, INFERIOR, MECHANISMS, LEADS, DURATION |
| الوصف: | ST-segment elevation in a structurally normal heart is associated with an electrocardiographic (ECG) J wave, which can be observed in the early repolarization syndrome (ERS), idiopathic ventricular fibrillation (VF), and the Brugada syndrome. Animal studies have demonstrated that the J wave is the consequence of a transmural voltage gradient resulting from an I-to-mediated action potential notch (spike and dome) in epicardium but not endocardium. I-to-mediated spike and dome morphology predisposes loss or depression of the dome in epicardium, leading to ST-segment elevation. Despite the fact that 3 clinical syndromes share many common ECG features, their clinical consequences are remarkably different. The ERS is a benign ECG finding characterized by a distinct J wave and ST segment in left precordial leads V-4 through V-6. In contrast, idiopathic VF and the Brugada syndrome, characterized by a J wave and ST-segment elevation in the inferior and right precordial leads, respectively, are the leading causes for sudden cardiac death in young Southeast Asian males. The underlying mechanism for such a difference in clinical consequences among these syndromes is due to a difference in I-to density and I-to-mediated epicardial spike and dome. When I-to is prominent, complete loss of the dome may occur due to either a decrease in inward currents or an increase in outward currents, leading to phase 2 reentry capable of initiating VF as in idiopathic VF and the Brugada syndrome. When I-to is relatively small as in the ERS, partial depression of the dome occurs without the development of phase 2 reentry. (c) 2005 Elsevier Inc. All rights reserved. ; Cardiac & Cardiovascular Systems ; SCI(E) ; CPCI-S(ISTP) ; 50 |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| تدمد: | 0022-0736 |
| العلاقة: | JOURNAL OF ELECTROCARDIOLOGY.2005/10/1,38(26-32).; 992800; http://hdl.handle.net/20.500.11897/253930Test; WOS:000233191000006 |
| DOI: | 10.1016/j.jelectrocard.2005.06.006 |
| الإتاحة: | https://doi.org/20.500.11897/253930Test https://doi.org/10.1016/j.jelectrocard.2005.06.006Test https://hdl.handle.net/20.500.11897/253930Test |
| رقم الانضمام: | edsbas.C481EB24 |
| قاعدة البيانات: | BASE |
| تدمد: | 00220736 |
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| DOI: | 10.1016/j.jelectrocard.2005.06.006 |