التفاصيل البيبلوغرافية
| العنوان: |
Presentation1_A Hierarchical Transcriptional Regulatory Network Required for Long-Term Thermal Stress Tolerance in an Industrial Saccharomyces cerevisiae Strain.PDF |
| المؤلفون: |
Yuman Gan (5075717), Xianni Qi (1403548), Yuping Lin (245217), Yufeng Guo (563481), Yuanyuan Zhang (101797), Qinhong Wang (239716) |
| سنة النشر: |
2022 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biotechnology, Biological Engineering, Genetic Engineering, Biomarkers, Biomaterials, Biomechanical Engineering, Biomedical Engineering not elsewhere classified, Synthetic Biology, Agricultural Marine Biotechnology, Bioremediation, Bioprocessing, Bioproduction and Bioproducts, Industrial Biotechnology Diagnostics (incl. Biosensors), Industrial Microbiology (incl. Biofeedstocks), Industrial Molecular Engineering of Nucleic Acids and Proteins, Industrial Biotechnology not elsewhere classified, Medical Biotechnology Diagnostics (incl. Biosensors), Medical Molecular Engineering of Nucleic Acids and Proteins, Regenerative Medicine (incl. Stem Cells and Tissue Engineering), Medical Biotechnology not elsewhere classified, transcriptional regulatory network, transcription factor, RNA sequencing, long-term thermal stress tolerance, industrial strain, Saccharomyces cerevisiae |
| الوصف: |
Yeast cells suffer from continuous and long-term thermal stress during high-temperature ethanol fermentation. Understanding the mechanism of yeast thermotolerance is important not only for studying microbial stress biology in basic research but also for developing thermotolerant strains for industrial application. Here, we compared the effects of 23 transcription factor (TF) deletions on high-temperature ethanol fermentation and cell survival after heat shock treatment and identified three core TFs, Sin3p, Srb2p and Mig1p, that are involved in regulating the response to long-term thermotolerance. Further analyses of comparative transcriptome profiling of the core TF deletions and transcription regulatory associations revealed a hierarchical transcriptional regulatory network centered on these three TFs. This global transcriptional regulatory network provided a better understanding of the regulatory mechanism behind long-term thermal stress tolerance as well as potential targets for transcriptome engineering to improve the performance of high-temperature ethanol fermentation by an industrial Saccharomyces cerevisiae strain. |
| نوع الوثيقة: |
conference object |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/presentation/Presentation1_A_Hierarchical_Transcriptional_Regulatory_Network_Required_for_Long-Term_Thermal_Stress_Tolerance_in_an_Industrial_Saccharomyces_cerevisiae_Strain_PDF/18584750Test |
| DOI: |
10.3389/fbioe.2021.826238.s001 |
| الإتاحة: |
https://doi.org/10.3389/fbioe.2021.826238.s001Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.81863C4 |
| قاعدة البيانات: |
BASE |
