مؤتمر
Anamnestic expansion of Omicron-reactive CD8 + T cells after booster SARS-CoV-2 mRNA vaccination across different immunocompromised states
| العنوان: | Anamnestic expansion of Omicron-reactive CD8 + T cells after booster SARS-CoV-2 mRNA vaccination across different immunocompromised states |
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| المؤلفون: | Mueller, Thomas R., Sekine, Takuya, Trubach, Darya, Niessl, Julia, Olofsson, Anna, Gao, Yu, Cai, Curtis, Nowak, Piotr, Blennow, Ola, Hansson, Lotta, Mielke, Stephan, Bergman, Peter, Ljunggren, Hans-Gustaf, Karlsson, Annika C., Saini, Sunil K., Aleman, Soo, Buggert, Marcus |
| المصدر: | Mueller , T R , Sekine , T , Trubach , D , Niessl , J , Olofsson , A , Gao , Y , Cai , C , Nowak , P , Blennow , O , Hansson , L , Mielke , S , Bergman , P , Ljunggren , H-G , Karlsson , A C , Saini , S K , Aleman , S & Buggert , M 2023 , ' Anamnestic expansion of Omicron-reactive CD8 + T cells after booster SARS-CoV-2 mRNA vaccination across different immunocompromised states ' , Journal of Immunology , vol. 210 , .... |
| سنة النشر: | 2023 |
| المجموعة: | Technical University of Denmark: DTU Orbit / Danmarks Tekniske Universitet |
| مصطلحات موضوعية: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | Restricted immune responses to SARS-CoV-2 mRNA vaccination have been observed frequently in individuals suffering from various immunodeficiencies. With increased antibody evasion properties of rising Omicron subvariants, there is a need to assess if other components of adaptive immunity generate resilient responses against SARS-CoV-2 across immunodeficient states. Here we assessed T cell responses of n=279 individuals covering five different immunodeficiencies and healthy controls before and after booster vaccination and - in a subset of patients - additional Omicron infection. We observed significantly increased Omicron-reactive T cell responses upon booster vaccination, particularly in initial poor responders, across all patient groups. Overall T cell composition shifted towards an increased CD8/CD4-ratio, which was accompanied by a more pronounced cytotoxic profile. Moreover, Omicron-reactive T cell responses showed signs of longevity represented by a novel T EMRA subpopulation with stem-cell-like characteristics and increased proliferative capacity. Regardless of underlying immunodeficiency, booster-vaccinated and Omicron-infected individuals were protected against severe disease and exhibited ameliorated and diversified T cell responses directed explicitly against Omicron, despite a solid immunological imprint of multiple wildtype Wuhan-based vaccine doses. |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| العلاقة: | https://orbit.dtu.dk/en/publications/c94cb0c3-68ce-4b2b-9c4c-3c513ccb7dc3Test |
| DOI: | 10.4049/jimmunol.210.Supp.75.16 |
| الإتاحة: | https://doi.org/10.4049/jimmunol.210.Supp.75.16Test https://orbit.dtu.dk/en/publications/c94cb0c3-68ce-4b2b-9c4c-3c513ccb7dc3Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.AA5B6220 |
| قاعدة البيانات: | BASE |
| DOI: | 10.4049/jimmunol.210.Supp.75.16 |
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