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1مؤتمر
المؤلفون: Linton, Kim, Ferreri, Andrés J M, Cwynarski, Kate, Pulczynski, Elisa, Fox, Christopher P, Schorb, Elisabeth, Rosée, Paul La, Binder, Mascha, Fabbri, Alberto, Torri, Valter, Minacapelli, Eleonora, Falautano, Monica, Ilariucci, Fiorella, Ambrosetti, Achille, Roth, Alexander, Hemmaway, Claire, Johnson, Peter, Pukrop, Tobias, Gørløv, Jette Sønderskov, Balzarotti, Monica, Hess, Georg, Keller, Ulrich, Stilgenbauer, Stephan, Panse, Jens, Tucci, Alessandra, Orsucci, Lorella, Pisani, Francesco, Levis, Alessandro, Krause, Stefan W, Schmoll, Hans J, Hertenstein, Bernd, Rummel, Mathias, Smith, Jeffery, Pfreundschuh, Michael, Cabras, Giuseppina, Angrilli, Francesco, Ponzoni, Maurilio, Deckert, Martina, Politi, Letterio S, Finke, Jürgen, Reni, Michele, Cavalli, Franco, Zucca, Emanuele, Illerhaus, Gerald
المصدر: Linton , K , Ferreri , A J M , Cwynarski , K , Pulczynski , E , Fox , C P , Schorb , E , Rosée , P L , Binder , M , Fabbri , A , Torri , V , Minacapelli , E , Falautano , M , Ilariucci , F , Ambrosetti , A , Roth , A , Hemmaway , C , Johnson , P , Pukrop , T , Gørløv , J S , Balzarotti , M , Hess , G , Keller , U , Stilgenbauer , S , Panse , ....
مصطلحات موضوعية: Primary CNS lymphoma, Consolidation therapy, Whole brain radiotherapy, Autlogous Stem Cell Transplant, Neurocognitive impairment, MATRix, ResearchInstitutes_Networks_Beacons/03/03, Cancer, ResearchInstitutes_Networks_Beacons/mcrc, Manchester Cancer Research Centre
الوصف: Introduction: IELSG32 is an international randomized phase II trial with 2 key clinical questions in pts with PCNSL. The first question focused on optimal induction therapy, and results of the 1st randomization have demonstrated that MATRix combination (methotrexate (MTX), cytarabine (ARAC), thiotepa, rituximab (R)) is associated with significantly better outcome [Ferreri AJ, et al. Lancet Haematol 2016]. The second question addresses the efficacy and neurotolerability of ASCT, as an alternative to WBRT as consolidation. Herein, we report the results of the 2nd randomization (NCT01011920). Methods: HIV-neg pts 18-70 ys and ECOG PS ≤3 with new histology-proven PCNSL and measurable disease were randomly assigned to receive 4 courses of MTX-ARAC (arm A); or R-MTX-ARAC (arm B); or MATRix (arm C). ASC were collected after 2nd c. Pts with responsive or stable disease were further randomized between WBRT 36 ± 9 Gy (arm D) and BCNU-thiotepa conditioned/ASCT (arm E). Stratification parameters were induction arm and response . Primary endpoint of the 2ndrandomization was 2-year PFS. To demonstrate a 2-yr PFS improvement from 65% (P0) to 85% (P1), 52 pts/arm (one-sided; α 5%; β 95%) were required. Consolidation arm would be considered effective if ≥40 pts were progression-free survivors at 2 ys. Analyses were performed on an intention-to-treat (ITT) basis. Effects of consolidation treatments on neurocognitive functions and quality of life (QoL) were assessed with the IPCG tests panel and EORTC-QLQ at baseline, after treatment and every 6 months afterwards. Results: 227 pts were enrolled in 52 centers of 5 countries; 219 assessable pts were referred to 1st randomization (arm A 75; B 69; C 75). 167 pts had responsive or stable disease after induction: 49 pts were excluded from 2nd randomization (poor mobilization, poor condition or patients’ refusal); 118 pts were thus randomized (59 pts/arm) and constitute the study population (median age 58 ys; range 18-70). 15 (13%) pts had high IELSG risk, 3 pts had ocular disease and 20 ...
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2مؤتمر
المؤلفون: Kuchenbauer, Florian, Bunjes, Donald W., Herr, Wolfgang, Heuser, Michael, Spaeth, Daniela, Casper, Jochen, Horst, Heinz August, Brossart, Peter, Held, Gerhard, Kobbe, Guido, Ringhoffer, Mark, Wattad, Mohammed, Salih, Helmut R., Goetze, Katharina S., Wulf, Gerald, Theobald, Matthias, Rummel, Mathias J., Fiedler, Walter, Westermann, Joerg, Salwender, Hans, Petzer, Andreas L., Hartmann, Frank, Luebbert, Michael, Martens, Uwe M., Greil, Richard, Kirchner, Hartmut H., Paschka, Peter, Gaidzik, Verena I., Teleanu, Veronica, Thol, Felicitas, Goehring, Gudrun, Doehner, Konstanze, Ganser', Arnold, Doehner, Hartmut, Schlenk, Richard F.
العلاقة: 56th Annual Meeting of the American-Society-of-Hematology; San Francisco, CA; https://resolver.sub.uni-goettingen.de/purl?gro-2/31531Test; 000349243504126
النص الكامل