مؤتمر
A genome-wide scan in affected sibling pairs with idiopathic recurrent miscarriage suggests genetic linkage
| العنوان: | A genome-wide scan in affected sibling pairs with idiopathic recurrent miscarriage suggests genetic linkage |
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| المؤلفون: | Kolte, Astrid Marie, Nielsen, H S, Moltke, Ida, Degn, B, Pedersen, Bjørn, Sunde, Lone E. M., Nielsen, F C, Christiansen, Ole Bjarne |
| المصدر: | Kolte , A M , Nielsen , H S , Moltke , I , Degn , B , Pedersen , B , Sunde , L E M , Nielsen , F C & Christiansen , O B 2011 , ' A genome-wide scan in affected sibling pairs with idiopathic recurrent miscarriage suggests genetic linkage ' , Journal of Reproductive Immunology , vol. 90 , no. 2 , pp. 147 . https://doi.org/10.1093/molehr/gar003Test |
| سنة النشر: | 2011 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | Abortion, Habitual, Adolescent, Adult, Chromosome Mapping, Denmark, Female, Genetic Predisposition to Disease, Genetic Testing, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Lod Score, Oligonucleotide Array Sequence Analysis, Pregnancy, Risk Factors, Siblings, Software |
| الوصف: | Previously, siblings of patients with idiopathic recurrent miscarriage (IRM) have been shown to have a higher risk of miscarriage. This study comprises two parts: (i) an epidemiological part, in which we introduce data on the frequency of miscarriage among 268 siblings of 244 patients with IRM and (ii) a genetic part presenting data from a genome-wide linkage study of 38 affected sibling pairs with IRM. All IRM patients (probands) had experienced three or more miscarriages and affected siblings two or more miscarriages. The sibling pairs were genotyped by the Affymetrix GeneChip 50K XbaI platform and non-parametric linkage analysis was performed via the software package Merlin. We find that siblings of IRM patients exhibit a higher frequency of miscarriage than population controls regardless of age at the time of pregnancy. We identify chromosomal regions with LOD scores between 2.5 and 3.0 in subgroups of affected sibling pairs. Maximum LOD scores were identified in four occurrences: for rs10514716 (3p14.2) when analyzing sister-pairs only; for rs10511668 (9p22.1) and rs341048 (11q13.4) when only analyzing families where the probands have had four or more miscarriages; and for rs10485275 (6q16.3) when analyzing one sibling pair from each family only. We identify no founder mutations. Concluding, our results imply that IRM patients and their siblings share factors which increase the risk of miscarriage. In this first genome-wide linkage study of affected sibling pairs with IRM, we identify regions on chromosomes 3, 6, 9 and 11 which warrant further investigation in order to elucidate their putative roles in the genesis of IRM. |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| DOI: | 10.1093/molehr/gar003 |
| الإتاحة: | https://doi.org/10.1093/molehr/gar003Test https://pure.au.dk/portal/da/publications/a-genomewide-scan-in-affected-sibling-pairs-with-idiopathic-recurrent-miscarriage-suggests-genetic-linkageTest(4f82d7c9-6c4f-43e2-9c6b-00be29b53b14).html |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.20DD0D83 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/molehr/gar003 |
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