المؤلفون: Niu, G, Yang, J, Liu, J, Liu, Y, Wu, EX

مصطلحات موضوعية: Brain - pathology, Cerebral Ventricles - pathology, Ferric Compounds - diagnostic use, Hypoxia-Ischemia, Image Enhancement - methods

الوصف: Proceedings of the IEEE Engineering in Medicine and Biology Society Conference, 2008, p. 363-366 ; In this study, 10-day-old normal rats (n=6) and hypoxic-ischemic (H-I) neonatal rats (n=6) were injected with the micronsized iron oxide particles (MPIOs) into the anterior lateral ventricle. 2D and 3D high-spatial resolution MRI were performed with a 7T animal scanner 1 day before the MPIOs injection and hour 3, day 3, day 7 and day 14 after the MPIOs injection. Intraperitoneal injections of 5-bromo-2'-deoxyuridine (BrdU) were used to label newly produced cells, and were given thrice daily for 2 days before sacrifice. Immunohistochemistry and Prussian blue staining indicated that iron particles were inside the nestin+ and BrdU+ neural progenitor cells (NPCs), glial-fibrillary-acidic-protein-positive (GFAP+) astrocytes-like progenitor cells, and neuronal-nuclei-positive (NeuN+) mature neurons. Here we demonstrate that, in normal neonatal rat brain, the migrating pathway of the endogenous NPCs with MPIO is mainly along the rostral migratory stream to the olfactory bulb. In H-I neonatal rat brain, the migration of endogenous NPCs with MPIO is mainly towards the ischemic regions. Therefore, in vivo magnetic cell labeling of endogenous NPCs with MPIO and subsequently non-invasive, serial MRI monitoring should open up a new approach to probe into the mechanism of cell migration in the developmental brain under physiological and pathologic conditions. © 2008 IEEE. ; published_or_final_version

العلاقة: Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"; http://www.scopus.com/mlt/select.url?eid=2-s2.0-61849126270&selection=ref&src=s&origin=recordpageTest; Proceedings Of The 30Th Annual International Conference Of The Ieee Engineering In Medicine And Biology Society, Embs'08 - Personalized Healthcare Through Technology, 2008, p. 363-366; 366; 161995; http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=363&epage=366&date=2008&atitle=Magnetic+resonance+imaging+of+migrating+neuronal+precursors+in+normal+and+hypoxic-ischemic+neonatal+rat+brains+by+intraventricular+MPIO+labelingTest; eid_2-s2.0-61849126270; 363; http://hdl.handle.net/10722/62061Test

الإتاحة: https://doi.org/10.1109/IEMBS.2008.4649165Test
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=363&epage=366&date=2008&atitle=Magnetic+resonance+imaging+of+migrating+neuronal+precursors+in+normal+and+hypoxic-ischemic+neonatal+rat+brains+by+intraventricular+MPIO+labelingTest
http://hdl.handle.net/10722/62061Test

المؤلفون: Hadzri, Edi Azali, Shamsudin, Amir Hamzah, Osman, Kahar, Abdul Kadir, Mohammed Rafiq, Aziz, Azian Abd

المصدر: AIP Conference Proceedings; 6/30/2012, Vol. 1440 Issue 1, p659-664, 6p

مصطلحات موضوعية: CEREBROSPINAL fluid, HYDROCEPHALUS, CEREBRAL ventricles, PRESSURE drop (Fluid dynamics), MAGNETIC resonance imaging of the brain, MATHEMATICAL models, NEWTONIAN fluids, COMPUTER software

مستخلص: Hydrocephalus is an abnormal accumulation of fluid in the ventricles and cavities in the brain. It occurs when the cerebrospinal fluid (CSF) flow or absorption is blocked or when excessive CSF is secreted. The excessive accumulation of CSF results in an abnormal widening of the ventricles. This widening creates potentially harmful pressure on the tissues of the brain. In this study, flow analysis of CSF was conducted on a three-dimensional model of the third ventricle and aqueduct of Sylvius, derived from MRI scans. CSF was modeled as Newtonian Fluid and its flow through the region of interest (ROI) was done using EFD. Lab software. Different steady flow rates through the Foramen of Monro, classified by normal and hydrocephalus cases, were modeled to investigate its effects. The results show that, for normal and hydrocephalus cases, the pressure drop of CSF flow across the third ventricle was observed to be linearly proportionally to the production rate increment. In conclusion, flow rates that cause pressure drop of 5 Pa was found to be the threshold for the initial sign of hydrocephalus. [ABSTRACT FROM AUTHOR]

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المؤلفون: Saad, William A., Luiz, A. C., Camargo, L. A A, Silveira, J. E N, Fóglia, S., Menani, José Vanderlei

المساهمون: Universidade Estadual Paulista (UNESP)

مصطلحات موضوعية: carbachol, central angiotensin, pressor response, angiotensin, losartan, losartan potassium, ramipril, animal experiment, cholinergic system, conference paper, controlled study, intracerebroventricular drug administration, male, nonhuman, rat, renin angiotensin aldosterone system, Angiotensin-Converting Enzyme Inhibitors, Animals, Blood Pressure, Cerebral Ventricles, Cholinergic Agonists, Pressoreceptors, Rats, Sprague-Dawley, Receptors, Renin-Angiotensin System, Animalia

الوصف: We investigated the effects of losartan, an AT 1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l μl) into the LV blocked the pressor response induced by ANG II (12 ng/l μl) and carbachol (2 nmol/l μl). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 ± 1 and 28 ± 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 ± 1 and 5 ± 2 mmHg, respectively). The injection of ramipril (12 ng/l μl) prior to carbachol blocked the pressor effect of carbachol to 7 ± 3 mmHg. These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure.

وصف الملف: 493-496

العلاقة: Brazilian Journal of Medical and Biological Research; 1.492; http://dx.doi.org/10.1590/S0100-879X1997000400010Test; Brazilian Journal of Medical and Biological Research, v. 30, n. 4, p. 493-496, 1997.; http://hdl.handle.net/11449/65079Test; S0100-879X1997000400010; WOS:A1997WT02000010; 2-s2.0-0030958097; 2-s2.0-0030958097.pdf; 1023597870118105

الإتاحة: https://doi.org/10.1590/S0100-879X1997000400010Test
http://hdl.handle.net/11449/65079Test

المؤلفون: Dobrovolskytė, Ugnė, Žiogaitė, Raimonda

المصدر: Jaunųjų mokslininkų ir tyrėjų konferencija [69-oji] – JMTK : tezių knyga 2017 : [2017 m. gegužės 17-19 d., Kaunas] / Lietuvos sveikatos mokslų universiteto (LSMU) Studentų mokslinė draugija (SMD) ; [Sudarė : Tadas Vanagas, Artūras Jacinavičius], Kaunas : Lietuvos sveikatos mokslų universiteto Studentų mokslinė draugija, 2017, p. 430-432

مصطلحات موضوعية: Cerebral ventricles, surgery, Drainage, methods, Postoperative complications, Central nervous system infections, etiology, info:eu-repo/classification/udc/616.8-022

العلاقة: http://lsmu.lvb.lt/LSMU:ELABAPDB22749210&prefLang=en_USTest

الإتاحة: http://lsmu.lvb.lt/LSMU:ELABAPDB22749210&prefLang=en_USTest

المؤلفون: Nag, S, Yee, BK, Tang, F

مصطلحات موضوعية: Amyloid Beta-Peptides - Pharmacology, Animals, Cerebral Cortex - Drug Effects - Metabolism, Cerebral Ventricles - Drug Effects - Physiology, Choline O-Acetyltransferase - Metabolism, Hippocampus - Drug Effects - Metabolism, Infusions, Parenteral, Male, Maze Learning - Drug Effects, Neuropeptides - Metabolism, Peptide Fragments - Pharmacology, Rats, Sprague-Dawley

الوصف: link_to_subscribed_fulltext

العلاقة: Annals of the New York Academy of Sciences; http://www.scopus.com/mlt/select.url?eid=2-s2.0-0033378754&selection=ref&src=s&origin=recordpageTest; Annals Of The New York Academy Of Sciences, 1999, v. 897, p. 420-422; 422; 53240; WOS:000085327400038; eid_2-s2.0-0033378754; 420; http://hdl.handle.net/10722/173442Test; 897

الإتاحة: https://doi.org/10.1111/j.1749-6632.1999.tb07911.xTest
http://hdl.handle.net/10722/173442Test

المؤلفون: Tang, F, Yee, BKY, Nag, S

مصطلحات موضوعية: Infusions, Parenteral, Male, Maze Learning - Drug Effects, Neuropeptides - Metabolism, Rats, Peptide Fragments - Pharmacology, Sprague-Dawley, Amyloid Beta-Peptides - Pharmacology, Animals, Cerebral Cortex - Drug Effects - Metabolism, Cerebral Ventricles - Drug Effects - Physiology, Choline O-Acetyltransferase - Metabolism, Hippocampus - Drug Effects - Metabolism

الوصف: Neuropeptides: Structure and Function in Biology and Behavior: Part 8. Poster Papers ; link_to_subscribed_fulltext

العلاقة: Annals of the New York Academy of Sciences; http://www.scopus.com/mlt/select.url?eid=2-s2.0-0033378754&selection=ref&src=s&origin=recordpageTest; Annals of the New York Academy of Sciences, 1999, v. 897, p. 420-422; 422; 53240; 47044; WOS:000085327400038; eid_2-s2.0-0033378754; Tang, F=7201979770; 420; http://hdl.handle.net/10722/104924Test; 897

الإتاحة: https://doi.org/10.1111/j.1749-6632.1999.tb07911.xTest
http://hdl.handle.net/10722/104924Test

المؤلفون: O'callaghan, E, Jones, P, Murray, RM, Takei, N, Sham, P

مصطلحات موضوعية: Brain Damage, Chronic - Genetics - Psychology, Cerebral Cortex - Pathology, Cerebral Ventricles - Pathology, Prenatal Exposure Delayed Effects, Risk Factors, Schizophrenia - Genetics, Schizophrenic Psychology, Social Environment, Delirium, Dementia, Amnestic, Cognitive Disorders - Genetics - Psychology, Female, Humans, Orthomyxoviridae - Genetics, Personality Development, Pregnancy, psy, hisphilso

الوصف: Recent neuroimaging and neuropathological studies suggest a developmental origin for schizophrenia. Some cases may, therefore, be caused by a genetic defect in the specification of brain development. Early environmental hazards such as obstetric complications, and maternal exposure during pregnancy to influenza epidemics, have also been found to increase the risk of later schizophrenia. The relationship between the prevalence of influenza and birth date has been found more consistently for female than male schizophrenics. Female schizophrenia is also associated with a higher risk of schizophrenia in first degree relatives. This raises the question of whether part of the genetic predisposition to schizophrenia may comprise an abnormal reaction to maternal influenza. ; link_to_subscribed_fulltext

العلاقة: https://doi.org/10.1016/0022-3956Test(92)90029-N

الإتاحة: https://doi.org/10.1016/0022-3956Test(92)90029-N