التفاصيل البيبلوغرافية
| العنوان: |
Transcription Factor Brn-3α mRNA in Cancers, Relationship with AR, ER Receptors and AKT/m-TOR Pathway Components. |
| المؤلفون: |
Spirina, L. V., Gorbunov, A. K., Chigevskaya, S. Y., Usynin, Y. A., Kondakova, I. V., Slonimskaya, E. M., Usynin, E. A., Choinzonov, E. L., Zaitseva, O. S. |
| المصدر: |
AIP Conference Proceedings; 2017, Vol. 1882 Issue 1, p1-6, 6p, 4 Charts |
| مصطلحات موضوعية: |
MESSENGER RNA, TRANSCRIPTION factors, MTOR inhibitors, ANTINEOPLASTIC agents, MTOR protein |
| مستخلص: |
Transcription factors POU4F1 (neurogenic factor Brn-3α) play a pivotal role in cancers development. The aim of the study was to reveal the Brn-3α expression, AR, ER expression in cancers development, association with AKT/mTOR pathway activation. 30 patients with locally advanced prostate cancer, 20 patients with papillary thyroid cancer, T2-3N0-1M0 stages and 40 patients with renal cell cancer T2-3N0M0-1 were involved into the study. The expressions of Brn-3α, AR, ERα, components of AKT/m-TOR signaling pathway genes were performed by real-time PCR. The dependence of Brn-3α expression on mRNA levels of steroid hormone receptors and components of AKT/m-TOR signaling pathway in studied cancers were shown. High levels of mRNA of nuclear factor, steroid hormone receptors were found followed by the activation of this signaling pathway in prostate cancer tissue. The reduction of transcription factor Brn-3α was accompanied with tumor invasive growth with increasing rates of AR, ER and 4E-BP1 mRNA. Thyroid cancer development happened in a case of a Brn-3α and steroid hormone receptors decrease. The activation of AKT/m-TOR signaling pathway was established in the metastatic renal cancers, accompanied with the increase of ER mRNA. But there was no correlation between the steroid receptor and Brn-3α. One-direction changes of Brn-3α were observed in the development of prostate and thyroid cancer due to its effect on the steroid hormone receptors and the activation of AKT/m-TOR signaling pathway components. The influence of this factor on the development of the kidney cancer was mediated through m-TOR activity modifications, the key enzyme of oncogenesis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
