مؤتمر
Anti-VEGF treatment in Pseudoxanthoma elasticum: preliminary results of a long-term ophthalmological follow-up
| العنوان: | Anti-VEGF treatment in Pseudoxanthoma elasticum: preliminary results of a long-term ophthalmological follow-up |
|---|---|
| المؤلفون: | De Vilder, Eva, De Zaeytijd, Julie, Leroy, Bart, Vanakker, Olivier |
| المصدر: | ABCC6-Budapest meeting, Abstracts |
| سنة النشر: | 2015 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, lucentis, avastin, anti-VEGF therapy, retinopathy, Pseudoxanthoma elasticum, ABCC6 |
| الوصف: | The pseudoxanthoma elasticum (PXE) retinopathy is characterized by peau d’orange and angioid streaks, with choroidal neovascularization, subretinal bleeding and (central) blindness as most severe complications. Among all features in the PXE phenotypic spectrum, the retinopathy is considered to have the highest impact on quality of life of PXE patients. The introduction of anti-angiogenic treatment using antibodies against Vascular Endothelial Growth Factor (VEGF), such as ranibizumab or bevacizumab over a decade ago and more recently aflibercept, led to a tremendous improvement of the patients’ ophthalmological prognoses by preventing blindness in numerous PXE patients. As such it has become the standard-of-care in the treatment of the complications resulting from the PXE retinopathy. Moreover, in some cases, intra-ocular anti-VEGF injections are being used in a preventive manner. In this study, we have compared fundus imaging of patients prior to the anti-VEGF era with patients who underwent multiple anti-VEGF injections. Further, the PXE patient cohort treated with anti-VEGF drugs was thoroughly assessed with longitudinal follow up comparing the ophthalmological phenotype prior to and after treatment. Visual acuity, anatomical and functional characteristics of the retinopathy were characterized using BCVA measurement (1/20: 2 letters; starting from 1/10: 5 letters per vision level), slit-lamp, Goldman visual field examination and optical coherence tomography (OCT), fundus imaging with white light, infrared and blue reflectance, infrared and blue autofluorescence and a fluorescein angiography if needed. We will describe the evolution of the ophthalmological phenotype with and without anti-VEGF treatment. Importantly, we observed retinal fibrosis in some of our patients who underwent multiple anti-VEGF injections in order to preserve their eyesight. Fibrosis, a complication, which has already been described in proliferative diabetic retinopathy, can indeed on its own deteriorate the patients’ vision. Very ... |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/7051093Test; http://hdl.handle.net/1854/LU-7051093Test |
| الإتاحة: | https://biblio.ugent.be/publication/7051093Test http://hdl.handle.net/1854/LU-7051093Test |
| رقم الانضمام: | edsbas.AD566C48 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |