كتاب
Structural Modifications on Natural-based Products: Synthetic Strategies and Biological Applications
| العنوان: | Structural Modifications on Natural-based Products: Synthetic Strategies and Biological Applications |
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| المؤلفون: | Fonseca, André, Matos, Maria João Correia Pinto Carvalho de, Vázquez Rodríguez, Saleta, Viña Castelao, María Dolores, Vilar Varela, Santiago, Borges, Fernanda, Santana Penín, María Lourdes, Uriarte Villares, Eugenio |
| المساهمون: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica, Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| بيانات النشر: | MDPI |
| المجموعة: | Minerva - Repositorio institucional da Universidade de Santiago de Compostela (USC) |
| مصطلحات موضوعية: | Natural products, Coumarins, Resveratrol, Chalcones, Pharmacological applications |
| الوصف: | Coumarins are a class of heterocyclic compounds present in a significant quantity in several plants. The simplest coumarin, a benzene ring fused with a pyran-2-one heterocycle, was first discovered in the 19th century and since then, due to the synthetic accessibility and the biological properties of its derivatives, has been playing an important role in the Medicinal Chemistry field. In fact, coumarins have been previously described as anticancer, antiviral, anti-inflammatory, antimicrobial, enzymatic inhibitory and antioxidant agents.Another two interesting compounds found widely in nature are resveratrol derivatives and chalcones. Both families of compounds are known for having remarkable antioxidant activity, cardio- and neuroprotective effects, among other relevant biological properties. Therefore, we devised several synthetic strategies to incorporate these natural products in one compound, combining their potential as promising agents for the treatment of several illnesses. In our group, we have already synthesised multiple novel compounds incorporating into the coumarin scaffold the resveratrol or chalcones moieties with remarkable activities towards different pharmacological targets. In this work, we continue exploiting this strategy by incorporating different linkers at coumarin position 3, thus giving us a wide range of possibilities for new compounds |
| نوع الوثيقة: | book part |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-3-906980-55-3 3-906980-55-3 |
| العلاقة: | Electronic Conference on Synthetic Organic Chemistry;18; https://doi.org/10.3390/ecsoc-18-b023Test; Fonseca, A., Matos, M.J., Vazquez-Rodriguez, S., Viña, D., Vilar, S., Borges, F., Santana, L. & Uriarte, E. (2015). Structural Modifications on Natural-based Products: Synthetic Strategies and Biological Applications. In J.A. Seijas, M.P. Vázquez Tato & S.K. Lin, Proceedings ECSOC-18: The 18Th International Electronic Conference On Synthetic Organic Chemistry: November 1-30, 2014. MDPI. doi:10.3390/ecsoc-18-b023; http://hdl.handle.net/10347/25979Test |
| DOI: | 10.3390/ecsoc-18-b023 |
| الإتاحة: | https://doi.org/10.3390/ecsoc-18-b023Test http://hdl.handle.net/10347/25979Test |
| حقوق: | © 2015 by MDPI, Basel, Switzerland. Open Access ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.24B547BA |
| قاعدة البيانات: | BASE |
| ردمك: | 9783906980553 3906980553 |
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| DOI: | 10.3390/ecsoc-18-b023 |