كتاب
ADAPTIVE MR-GUIDED RADIOTHERAPY: FROM CONCEPT TO ROUTINE PRACTICE
| العنوان: | ADAPTIVE MR-GUIDED RADIOTHERAPY: FROM CONCEPT TO ROUTINE PRACTICE |
|---|---|
| المؤلفون: | Bohoudi, Omar |
| المصدر: | Bohoudi , O 2022 , ' ADAPTIVE MR-GUIDED RADIOTHERAPY: FROM CONCEPT TO ROUTINE PRACTICE ' , PhD , Vrije Universiteit Amsterdam , Amsterdam . |
| بيانات النشر: | sine nomine |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | MRI-geleide radiotherapie, Adaptieve radiotherapie, Stereotactische ablatieve radiotherapie, Dosis accumulatie, Gepersonaliseerde MRgRT, MR-guided radiatiotherapy, Adaptive radiatiotherapy, Stereotactic ablative radiotherapy, Dose accumulation, personalized MRgRT |
| الوصف: | Radiotherapy is an established curative treatment for cancer and is also widely used in the treatment of metastatic disease. Magnetic resonance guided radiotherapy (MRgRT) represents a major treatment advance as it permits precise soft tissue setup and the continuous visualization of tumors and surrounding organs, thereby improving the safety and effectiveness of radiotherapy delivery. MRgRT was first introduced clinically in 2014, and in 2016, the Amsterdam UMC became the first Dutch adopters, focusing on treating patients using stereotactic ablative radiotherapy (SABR). The work performed in this thesis describes a number of approaches developed in order to ensure a practical and feasible workflow for MRgRT delivery of SABR using daily on-couch adaptive treatment plan delivery whenever possible. A key development was the strategy for plan adaptation using only a single treatment optimization step that only requires clinicians to review and adjust organ contours located within 2-3 cm from the target. This novel and fast approach resulted in treatment plans meeting all clinical constraints, and contributed to the feasibility of using daily adaptive MRgRT, as plan adaptation added only about 15 minutes to the total workflow. Use of this strategy has led to more than 1200 patients undergoing 6000 treatment fractions to tumor in the prostate, pancreas, high-risk lung cancer, renal- and adrenal lesions, and liver metastases. Almost all fractions have been delivered using the adapted plan. The delivery of daily adapted MRgRT requires time slots of approximately 45 to 60 minutes for SABR delivery. To reduce treatment times further, it is essential to identify patients groups that are less likely to benefit from having a new daily radiotherapy plan, and our studies identified patients with abdominal tumors who could be treated faster without plan adaptation. This will permit a more efficient use of resources. Organs in the body can move during treatment, leading to a need for intrafractional adapted radiotherapy plans. ... |
| نوع الوثيقة: | book |
| وصف الملف: | application/pdf; image/jpeg |
| اللغة: | English |
| العلاقة: | https://research.vu.nl/en/publications/17dd454e-a586-40b0-a7ad-0f8c01813df0Test |
| الإتاحة: | https://research.vu.nl/en/publications/17dd454e-a586-40b0-a7ad-0f8c01813df0Test https://hdl.handle.net/1871.1/17dd454e-a586-40b0-a7ad-0f8c01813df0Test https://research.vu.nl/ws/files/154630182/O%20%20Bohoudi%20-%20thesis.pdfTest https://research.vu.nl/ws/files/154630184/O%20%20Bohoudi%20-%20cover.jpgTest https://research.vu.nl/ws/files/154630186/O%20%20Bohoudi%20-%20toc.pdfTest https://research.vu.nl/ws/files/154630188/O%20%20Bohoudi%20-%20title_page.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CE4BD202 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |