كتاب
In Vivo Studies of Protein Misfolding and Neurodegeneration Induced by Metabolic Syndrome Relative to Chronic Cerebral Hypoperfusion: A Critical Review
| العنوان: | In Vivo Studies of Protein Misfolding and Neurodegeneration Induced by Metabolic Syndrome Relative to Chronic Cerebral Hypoperfusion: A Critical Review |
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| المؤلفون: | Herrera, María I., Luaces, Juan Pablo, Udovin, Lucas D., Toro Urrego, Nicolas, Otero-losada, Matilde Estela, Capani, Francisco |
| المساهمون: | Otero-losada, Matilde Estela, Capani, Francisco, Perez Lloret, Santiago |
| بيانات النشر: | IntechOpen |
| المجموعة: | CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: | metabolic syndrome (MetS), chronic cerebral hypoperfusion (CCH), protein misfolding, https://purl.org/becyt/ford/3.1Test, https://purl.org/becyt/ford/3Test |
| الوصف: | Metabolic syndrome (MetS) leads to microvascular dysfunction and chronic cerebral hypoperfusion (CCH) in an insidious way. Clinical evidence and several rodent models have contributed to determining the neurodegenerative effect of a sustained decrease in cerebral blood flow (CBF). Protein misfolding and aggrega- tion derived from CCH might account for the establishment of vascular cognitive impairment and dementia (VCID) and Alzheimer?s disease (AD). However, the complex and multifactorial etiology of cerebrovascular disease demands the combination of experimental models in scientific research. In this sense, the present work aims at summarizing the differential available rodent paradigms for studying the establishment of cognitive decline resulting from protein misfolding inducedby MetS in association with CCH. Revising experimental findings in the field will help further basic research on the pathophysiology of cerebrovascular disease and the future testing of protein-remodeling factors as neuroprotective agents for the prevention of cognitive impairment. ; Fil: Herrera, María I. No especifíca; ; Fil: Luaces, Juan Pablo. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Udovin, Lucas D. No especifíca; ; Fil: Toro Urrego, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina ; Fil: Otero-losada, Matilde Estela. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; ... |
| نوع الوثيقة: | book part |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-1-83880-440-4 1-83880-440-4 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/url/https://www.intechopen.com/chapters/72902Test; http://hdl.handle.net/11336/129456Test; Herrera, María I.; Luaces, Juan Pablo; Udovin, Lucas D.; Toro Urrego, Nicolas; Otero-losada, Matilde Estela; et al.; In Vivo Studies of Protein Misfolding and Neurodegeneration Induced by Metabolic Syndrome Relative to Chronic Cerebral Hypoperfusion: A Critical Review; IntechOpen; 2020; 1-15; CONICET Digital; CONICET |
| الإتاحة: | https://doi.org/10.5772/intechopen.92603Test http://hdl.handle.net/11336/129456Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/arTest/ |
| رقم الانضمام: | edsbas.994169D3 |
| قاعدة البيانات: | BASE |
| ردمك: | 9781838804404 1838804404 |
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