المؤلفون: Paro, Renato, Grossniklaus, Ueli, Santoro, Raffaella, Wutz, Anton

مصطلحات موضوعية: Genetics and Genomics, Biomedicine, general, Cell Biology, Human Genetics, Epigenetics, Biomedical Research, Medical Genetics, Cancer, Chromatin, Chromatin Dynamics, Cellular Memory, DNA Methylation, Epigenetic Textbook, Gene Regulation, Gene Silencing, Histone Modification, Imprinting, Inheritance, Metabolism, Nucleus, Open Access, Pluripotency, Reprogramming, RNA Mechanisms, Transcription, X Chromosome inactivation, Genetics (non-medical), Medical research, Cellular biology (cytology), bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical), bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBG Medical equipment & techniques, bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry::PSBC Proteins, bic Book Industry Communication::M Medicine::MF Pre-clinical medicine: basic sciences::MFN Medical genetics

الوصف: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

وصف الملف: application/pdf

العلاقة: Learning Materials in Biosciences

الوصول الحر: https://library.oapen.org/handle/20.500.12657/48275Test

المؤلفون: Rasmussen, Kasper D, Helin, Kristian

المصدر: Rasmussen , K D & Helin , K 2021 , ChIP-Sequencing of TET Proteins . in TET Proteins and DNA Demethylation . vol. 2272 , Springer , Methods in molecular biology (Clifton, N.J.) , vol. 2272 , pp. 251-262 . https://doi.org/10.1007/978-1-0716-1294-1_15Test

مصطلحات موضوعية: Chromatin Immunoprecipitation Sequencing/methods, DNA Methylation, Humans, Mixed Function Oxygenases/classification, Proto-Oncogene Proteins/classification, Sequence Analysis, DNA/methods

الوصف: TET proteins are methylcytosine dioxygenases that interact directly with chromatin to shape the DNA methylation landscape. To increase the understanding of TET protein function in a specific cellular context, it is important to be able to map the interactions between TET proteins and DNA. This ChIP-seq protocol details our procedure to analyze TET2 bound DNA in disuccinimidyl glutarate (DSG) and formaldehyde-crosslinked chromatin but can also be adapted to study other TET enzymes.

الإتاحة: https://doi.org/10.1007/978-1-0716-1294-1_15Test
https://curis.ku.dk/portal/da/publications/chipsequencing-of-tet-proteinsTest(6f3ef10e-4cb3-4ce1-978c-808578632776).html

المؤلفون: Schmolka, Nina, Silva-Santos, Bruno, Gomes, Anita Q.

مصطلحات موضوعية: Chromatin, Histone methylation, DNA methylation, lncRNAs, miRNAs, T-cell differentiation, B-cell differentiation, Gene expression regulation

الوصف: Epigenetics refers to heritable phenotype changes that do not involve alterations in the DNA sequence. While DNA methylation and histone modifications represent the classical epigenetic mechanisms, RNA-based interference can also be integrated into the epigenetic machinery. In particular, microRNAs play important roles in regulating gene expression at the posttranscriptional level. Thus, from the nucleus to the cytoplasm, various “epigenetic” mechanisms can control cell fate decisions and differentiation. This has been extensively documented in lymphocyte biology, from a commitment to the B- and T-cell lineages to the differentiation of multiple effector lymphocyte subsets. Here we review the accumulated knowledge that fundaments our understanding of how classical epigenetics and RNA-based regulatory mechanisms impact B- and T-cell differentiation. ; info:eu-repo/semantics/publishedVersion

العلاقة: https://www.sciencedirect.com/science/article/pii/B9780128179642000046Test; Schmolka N, Silva-Santos B, Gomes AQ. Epigenetic mechanisms in the regulation of lymphocyte differentiation. In: Kabelitz D, Bhat J, editors. Epigenetics of the immune system. San Diego: Academic Press; 2020. p. 77-116.; http://hdl.handle.net/10400.21/12109Test

الإتاحة: https://doi.org/10.1016/B978-0-12-817964-2.00004-6Test
http://hdl.handle.net/10400.21/12109Test

المؤلفون: Bagella, Luigi Marco, Marchesi, Irene

المساهمون: Bagella, Luigi Marco, Marchesi, Irene

مصطلحات موضوعية: Zeste homolog 2 (EZH2), polycomb repressive complex 2, chromatin structure, DNA methylation

الوصف: Epigenetics is a branch of genetics that focuses on the heritable changes of DNA or associated proteins, other than DNA sequence variations, which carry information content during cell division [1,2]. These heritable changes are ascribed to chromatin, which constitutes the ultrastructure of DNA and whose modifications affect the genetic material functionality. Differences in chromatin structure have been associated to transcription regulation [3-5] and chromosome stability [6,7], affecting both gene’s information, expression and heritability. Noteworthy, these epigenetic modifications are involved in both transcriptional activation and repression, indicating their widespread role as modulators of gene expression in numerous biological processes [8,9].Chromatin is subjected to numerous modifications roughly classified in two groups: DNA and histone post-translational modifications (histone-PTMs).DNA methylation is the most studied epigenetic modification of DNA and corresponds to the covalent addition of a methyl (CH3) group to the nucleotide cytosine within CG dinucleotides or CNG trinucleotides where N can be C, A, G or T. Usually, DNA methylation induces decreased protein-DNA binding of transcription factors and leads to the repression of gene expression [10].DNA “methylable” sequences are not uniform across the human genome but restricted in CpG rich DNA regions termed CpG islands (CGI). CGI are localized at repetitive sequences, heavy methylated, to prevent the reactivation of endoparasitic sequences such as transposons, and at gene promoter sequences, which are normally refractory to methylation in normal somatic cells [8,11].

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/978-953-51-1087-3; ispartofbook:Chromatin remodelling; firstpage:119; lastpage:152; http://hdl.handle.net/11388/262639Test

الإتاحة: https://doi.org/10.5772/55370Test
http://hdl.handle.net/11388/262639Test

المؤلفون: O’Rourke, Colm J., Satriano, Letizia, Oliveira, Douglas V.N.P., Munoz-Garrido, Patricia, Andersen, Jesper B.

المصدر: O’Rourke , C J , Satriano , L , Oliveira , D V N P , Munoz-Garrido , P & Andersen , J B 2019 , Therapeutic Potential of Pharmacoepigenetics in Cholangiocarcinoma . in Pharmacoepigenetics . Academic Press , pp. 551-562 . https://doi.org/10.1016/B978-0-12-813939-4.00017-6Test

مصطلحات موضوعية: Biliary tract, Cholangiocarcinoma, Chromatin, DNA methylation, Epimutation, Gemcitabine, Noncoding RNA, envir, stat

الوصف: Persistent increases in the incidence and mortality rates of biliary tract cancers implicate this heterogeneous group of malignancies as a growing threat to population health worldwide. The failure of current chemotherapy to extend median survival beyond one year highlights the extensive innate and rapidly acquired chemoresistance of these tumors, although the underlying molecular mechanisms remain opaque. Notably, a significant proportion of the mutational landscape in cholangiocarcinoma (CCA) comprises recurrent mutations in epigenetic regulators, implying extensive (epi)genome-wide consequences arising from mutant isoform activities. These findings suggest CCA may be a prime solid tumor candidate for epigenome-targeted therapies. In this chapter we assess the epigenomic architecture of CCA and subsequent indications for patient stratification and personalization of epigenetic therapy. From this we contextualize epigenetic therapies into different prospective clinical applications (including differentiation therapy, immune modulation, and chemosensitization). Finally, we discuss the challenges that must be overcome in future CCA epigenomics studies to improve the translation of research (basic and translational) findings into the clinic.

العلاقة: https://curis.ku.dk/portal/da/publications/therapeutic-potential-of-pharmacoepigenetics-in-cholangiocarcinomaTest(c76552fc-71f4-464e-be76-3393be2aee5f).html

الإتاحة: https://doi.org/10.1016/B978-0-12-813939-4.00017-6Test
https://curis.ku.dk/portal/da/publications/therapeutic-potential-of-pharmacoepigenetics-in-cholangiocarcinomaTest(c76552fc-71f4-464e-be76-3393be2aee5f).html

المؤلفون: Vidaković, Melita, Tolić, Anja, Grdović, Nevena, Ravichandran, Mirunalini, Jurkowski, Tomasz P.

المصدر: Handbook of Nutrition, Diet, and Epigenetics

مصطلحات موضوعية: Diabetes, DNA methylation, DNA demethylation, DNMT enzymes, Epigenetic drug targets, Chromatin architecture, PARylation, PARP-1 inhibitors, TET enzymes

الوصف: Diabetes and diabetic complications, autoimmunity and inflammatory diseases, have recently become the focus of epigenetic therapy, since with epigenetic drugs it is possible to reverse aberrant gene expression profiles associated with the disease states. For diabetes, the therapy challenges depend on identifying the most appropriate molecular target and its influence on a relevant gene product. This chapter summarizes the current view on the interplay between ten-eleven translocation (TETs) and the poly(ADP-ribose) polymerase (PARPs) family of enzymes in regulating DNA methylation and how this interplay could be targeted to attenuate diabetes. This molecular interchange jigsaw puzzle is emerging as an important focus of research, and we can expect to see further advances in the elucidation of its role in diabetes as well as other pathologies. Moreover, the possibility for designating specific PARP-1 inhibitors as potential “EPI-drugs” for diabetes prevention/attenuation is also discussed. Understanding the epigenetic machinery and the differential roles of its components is essential for the development of targeted epigenetic therapies for diseases. ; Patel VB, Preedy VR, editors. Handbook of Nutrition, Diet, and Epigenetics. Springer International Publishing; 2019. p. 1857–76.

العلاقة: https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-55530-0_55Test; https://radar.ibiss.bg.ac.rs/handle/123456789/3616Test; 2-s2.0-85079724776

الإتاحة: https://doi.org/10.1007/978-3-319-55530-0_55Test
https://radar.ibiss.bg.ac.rs/handle/123456789/3616Test

المؤلفون: Bassi, Silvia, Tripathi, Takshashila, Monziani, Alan, Di Leva, Francesca, Biagioli, Marta

المساهمون: Bassi, Silvia, Tripathi, Takshashila, Monziani, Alan, Di Leva, Francesca, Biagioli, Marta

مصطلحات موضوعية: CAG repeat expansion, Chromatin, Epigenetic, Histone acetylation/deacetylation, Histone and DNA methylation/demethylation, Huntington’s disease (HD), Long noncoding RNAs (lncRNAs), miRNA, Noncoding RNAs (ncRNAs), Acetylation, Animal, Cell Line, Chromatin Assembly and Disassembly, Clinical Trials as Topic, DNA Methylation, Disease Models, Epigenesis, Genetic, Gene Expression Regulation, Histone Code, Histone Deacetylase Inhibitor, Histone Deacetylase, Histone-Lysine N-Methyltransferase, Homeostasi, Human, Huntingtin Protein, Huntington Disease, Methylation, Myeloid-Lymphoid Leukemia Protein, Nerve Tissue Protein

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/978-3-319-53888-4; info:eu-repo/semantics/altIdentifier/isbn/978-3-319-53889-1; info:eu-repo/semantics/altIdentifier/pmid/28523552; info:eu-repo/semantics/altIdentifier/wos/WOS:000438240500015; ispartofbook:Advances in Experimental Medicine and Biology; volume:978; firstpage:277; lastpage:299; numberofpages:23; http://hdl.handle.net/11572/204622Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85020478750; http://www.springer.com/series/5584Test

الإتاحة: https://doi.org/10.1007/978-3-319-53889-1_15Test
http://hdl.handle.net/11572/204622Test
http://www.springer.com/series/5584Test

المؤلفون: ZAMPIERI, Michele, CICCARONE, FABIO, CAIAFA, Paola

المساهمون: Alexey Moskalev, Alexander M. Vaiserman, Zampieri, Michele, Ciccarone, Fabio, Caiafa, Paola

مصطلحات موضوعية: DNA methylation, DNA demethylation, aging, chromatin, histones

الوصف: The process of aging culminates in a multitude of chronological irreversible changes at the cellular and molecular levels that push the organism toward a progressive loss of physiological integrity and increased susceptibility to disease. Mounting evidence indicates that aging trajectories can be closely tracked down by changes in the DNA methylation patterns over the entire lifespan. The tracing of underlying mechanisms is a promising research path to gain a deeper understanding of the molecular nature of aging. Here we discuss current knowledge about dynamics of DNA methylation in mammals and describe changes in DNA methylation occurring during aging. We explore mechanisms that could underpin aging-related DNA methylation changes and highlight models in which those changes can be understood in the context of the complex interplay between DNA methylation, chromatin states and their modulators.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/978-0-12-811060-7; ispartofseries:Translational Epigenetics series; ispartofbook:Epigenetics of Aging and Longevity; volume:4; firstpage:33; lastpage:58; numberofpages:26; info:eu-repo/grantAgreement/EC/FP7/HEALTH-F4-2008-200880; http://hdl.handle.net/11573/1034322Test

الإتاحة: https://doi.org/10.1016/C2016-0-00707-6Test
http://hdl.handle.net/11573/1034322Test

المؤلفون: FRISO, Simonetta, PIZZOLO, Francesca, OLIVIERI, Oliviero, Carvajal, C. A., Fardella, C. E.

المساهمون: Laurence, J., Van Beusekom, M., Friso, Simonetta, Carvajal, C. A., Pizzolo, Francesca, Fardella, C. E., Olivieri, Oliviero

مصطلحات موضوعية: Arterial hypertension, Cardiovascular disease, Chromatin remodeling, DNA methylation, Epigenetic, Histone acetylation, Histone methylation, Histone modification, MicroRNA, Small noncoding RNAs

الوصف: Arterial hypertension; Cardiovascular diseases; Chromatin remodeling; DNA methylation; Epigenetics; Histone acetylation; Histone methylation; Histone modifications; MicroRNAs; Small noncoding RNAs

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/9780128008027; ispartofbook:Translating Epigenetics to the Clinic; firstpage:159; lastpage:184; numberofpages:26; alleditors:Laurence, J.; Van Beusekom, M.; http://hdl.handle.net/11562/962235Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85009843351

الإتاحة: https://doi.org/10.1016/B978-0-12-800802-7.00007-1Test
http://hdl.handle.net/11562/962235Test

المؤلفون: Masciarelli, Silvia, Bellissimo, Teresa, Iosue, Ilaria, Fazi, Francesco

المساهمون: Sabrina strano, Masciarelli, Silvia, Bellissimo, Teresa, Iosue, Ilaria, Fazi, Francesco

مصطلحات موضوعية: 5-methyl-cytosine, cancer chemoprevention, chromatin immunoprecipitation, CpG island, DNA methylation, epigenetic remodeling, MeDIP

الوصف: Epigenetic mechanisms such as DNA methylation, posttranslational modifications of histone proteins, remodeling of nucleosomes, and the expression of noncoding RNAs contribute to the regulation of gene expression for the cell fate determination and tissue development. The disruption of these epigenetic mechanisms, in conjunction with genetic alterations, is a decisive element for cancer development and progression. The cancer phenotype is characterized by global DNA hypomethylation and gene-specific hypermethylation. The methylated DNA immunoprecipitation [MeDIP] is a useful approach currently used to clarify the functional consequences of DNA methylation on cell fate determination and cancer development.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/978-1-4939-3190-3; info:eu-repo/semantics/altIdentifier/isbn/978-1-4939-3191-0; info:eu-repo/semantics/altIdentifier/pmid/26608290; ispartofbook:Cancer Chemoprevention methods and protocols; volume:1379; firstpage:69; lastpage:76; numberofpages:8; serie:METHODS IN MOLECULAR BIOLOGY; http://hdl.handle.net/11573/840688Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84948780941

الإتاحة: https://doi.org/10.1007/978-1-4939-3191-0_6Test
http://hdl.handle.net/11573/840688Test