المؤلفون: Hjorth, Kansadarat, Carbin Menyes, Erika

مصطلحات موضوعية: Type 1 diabetes mellitus, transfers, adolescence, adult, experiences, Typ 1 diabetes mellitus, övergÃ¥ng, barn, vuxen, erfarenheter, Nursing, OmvÃ¥rdnad

الوصف: Bakgrund: Incidensen för typ 1-diabetes ökar under barndomen vilket betyder att allt flera ungdomar kommer att genomgaÌŠ överföringen fraÌŠn barndiabetesmottagningen till vuxendiabetesmottagning. Syfte: Syftet med uppsatsen var att belysa upplevelsen av överföringen fraÌŠn barndiabetesmottagning till vuxendiabetesmottagning ur olika perspektiv. Metod: En kvalitativ metasyntes. Sökningar gjordes paÌŠ databaserna CINAHL och PubMed. Nio artiklar som svarar paÌŠ författarnas syfte hittades, aÌŠtta kvalitativa och en mixed-method. Resultat: Fyra huvudteman identifierades: utmaningar att navigera, stödets funktion, inför överföringen till VDM och förväntningar. Vidare identifierades undertema för tre av huvudteman. Underteman till utmaningar att navigera var: ungdomarnas maÌŠnga utmaningar att navigera livet med T1D och vaÌŠrdnadshavarnas utmaningar att navigera en ny roll. Underteman till inför överföringen var: tidigare förbereda överföringen och utbildning och upprepning av grunderna. Underteman till förväntningar var: innan överföringen och efter överföringen. Slutsats: Ungdomar genomgaÌŠr en stor förändring i livet och den sena tonaÌŠrstiden är präglad med stora förändringar och beslut. Överföringen fraÌŠn barndiabetesmottagning till vuxendiabetesmottagning utgör en extra saÌŠrbar tid för ungdomarna. Resultatet visar paÌŠ att baÌŠde ungdomarna och vaÌŠrdnadshavarna uttrycker stor oro och aÌŠngest inför överföringen. Det är viktigt att diabetessjuksköterskan tidigt börjar förbereda ungdomarna och vaÌŠrdnadshavarna inför överföringen för bästa möjliga resultat för alla inblandade. Ungdomarna uttrycker stor önskan om att faÌŠ repetition och utbildning i grunderna inom diabetes. ; Background: The incidence of type 1 diabetes increases during childhood, which means that more and more adolescence will undergo the transfer from the pediatric diabetes clinic to the adult diabetes clinic. Aim: The purpose was to ...

وصف الملف: application/pdf

العلاقة: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-530763Test

الإتاحة: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-530763Test

المؤلفون: Hakkarainen, Pirjo, Moilanen, Leena, Hänninen, Vilma, Heikkinen, Jarmo, Huttunen, Erja, Räsänen, Kimmo

المساهمون: Terveystieteiden tiedekunta, Faculty of Health Sciences

مصطلحات موضوعية: Diabetes Mellitus, Type 1, Adult, Health Status, Occupational Health, Occupational Health Services, nuoruustyypin diabetes, koettu terveys, salaus, työkyky, työhyvinvointi, työelämä, työikäiset, työterveyshuolto

وصف الملف: fulltext; Julkaisun kokoteksti; Fulltext of publication

العلاقة: Publications of the University of Eastern Finland. Reports and Studies in Health Sciences; https://erepo.uef.fi/handle/123456789/14443Test; http://urn.fi/URN:ISBN:978-952-61-0521-5Test

الإتاحة: https://erepo.uef.fi/handle/123456789/14443Test
http://urn.fi/URN:ISBN:978-952-61-0521-5Test

المؤلفون: Alyassin, Issam, Wahlström, Viktor

مصطلحات موضوعية: Adult, diabetes type 1, experience, patients, self-care, Egenvård, diabetes typ 1, patient, upplevelse, vuxen, Nursing, Omvårdnad

الوصف: Bakgrund: Diabetes typ 1 är en kronisk sjukdom som drabbar många människor i världen. Sjukdomen kan leda till många olika komplikationer om egenvård inte främjas. För att förebygga diabeteskomplikationer krävs det livsstilsförändring i form av hälsosam kost och fysiska aktiviteter. För att patienten ska vara delaktig i sin egenvård krävs det att sjuksköterskan framhäver patientens styrkor och motiverar dem till delaktighet i egenvård. Syfte: Att beskriva patienters upplevelser av egenvård vid diabetes typ 1. Metod: Metoden som användes i studien var en litteraturstudie baserad på kvalitativ forskning. 13 kvalitativa vetenskapliga artiklar med kvalitativ ansats granskades och analyserades genom Fribergs fem steg för en integrerande sammanfattning. Resultat: Patienter upplever att kunskap, stabila blodsockervärden, stöd från sjukvården, omgivningen och hjälpmedel ger känslan av trygghet. För att uppnå detta och kunna ta det egna ansvaret krävs att patienterna accepterar sin sjukdom och situationen som de befinner sig i. Rädsla och stress är ständigt närvarande hos patienterna och något som de behöver handskas med dagligen. Konklusion: Faktorer som påverkar blodsockernivåerna är något som ständigt är närvarande hos patienter med diabetes typ 1. Sjuksköterskans ansvarsområde är att utbilda patienterna utifrån deras individuella behov med syfte att öka kunskap, vilket bidrar till bättre egenvård och ökad trygghet i vardagen.
Background: Diabetes type 1 is a chronic disease that affects many people in the world. If there is no suitable self-care, this disease can lead to many different complications. To prevent diabetes complications, lifestyle changes in the form of a healthy diet and physical activities are required. For the patient to be involved in their care, the nurse must highlight the patient's strengths and motivate them to participate in self-care. Aim: To describe patients' experiences of self-care in diabetes type 1. Method: The method used in the study was a literature study based on qualitative research. 13 qualitative scientific articles with a qualitative approach were reviewed and analyzed through Friberg’s five steps for an integrative summary. Findings: Patients feel that knowledge, stable blood sugar values, support from the healthcare system, the environment and utils provide a sense of security. To achieve this and be able to take their own responsibility, patients must accept their illness and the situation they are in. Fear and stress are constantly present and something these patients need to deal with on a daily basis. Conclusion: Factors that affect blood sugar levels are constantly present in patients with type 1 diabetes. The nurse's area of responsibility is to educate patients based on their individual needs with the aim of increasing knowledge, which contributes to better self-care and increased security in everyday life.

وصف الملف: application/pdf

الإتاحة: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-23434Test

المؤلفون: Alyassin, Issam, Wahlström, Viktor

مصطلحات موضوعية: Adult, diabetes type 1, experience, patients, self-care, Egenvård, diabetes typ 1, patient, upplevelse, vuxen, Nursing, Omvårdnad

الوصف: Bakgrund: Diabetes typ 1 är en kronisk sjukdom som drabbar många människor i världen. Sjukdomen kan leda till många olika komplikationer om egenvård inte främjas. För att förebygga diabeteskomplikationer krävs det livsstilsförändring i form av hälsosam kost och fysiska aktiviteter. För att patienten ska vara delaktig i sin egenvård krävs det att sjuksköterskan framhäver patientens styrkor och motiverar dem till delaktighet i egenvård. Syfte: Att beskriva patienters upplevelser av egenvård vid diabetes typ 1. Metod: Metoden som användes i studien var en litteraturstudie baserad på kvalitativ forskning. 13 kvalitativa vetenskapliga artiklar med kvalitativ ansats granskades och analyserades genom Fribergs fem steg för en integrerande sammanfattning. Resultat: Patienter upplever att kunskap, stabila blodsockervärden, stöd från sjukvården, omgivningen och hjälpmedel ger känslan av trygghet. För att uppnå detta och kunna ta det egna ansvaret krävs att patienterna accepterar sin sjukdom och situationen som de befinner sig i. Rädsla och stress är ständigt närvarande hos patienterna och något som de behöver handskas med dagligen. Konklusion: Faktorer som påverkar blodsockernivåerna är något som ständigt är närvarande hos patienter med diabetes typ 1. Sjuksköterskans ansvarsområde är att utbilda patienterna utifrån deras individuella behov med syfte att öka kunskap, vilket bidrar till bättre egenvård och ökad trygghet i vardagen. ; Background: Diabetes type 1 is a chronic disease that affects many people in the world. If there is no suitable self-care, this disease can lead to many different complications. To prevent diabetes complications, lifestyle changes in the form of a healthy diet and physical activities are required. For the patient to be involved in their care, the nurse must highlight the patient's strengths and motivate them to participate in self-care. Aim: To describe patients' experiences of self-care in diabetes type 1. Method: The method used in the study was a literature study based on qualitative ...

وصف الملف: application/pdf

العلاقة: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-23434Test

الإتاحة: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-23434Test

المؤلفون: Mai, N.T.H, Phu, N.H, Nghia, H.D.T, Phuong, T.M, Duc, D.T, Chau, N.V.V, Wills, B, Lim, C.C.T, Thwaites, G, Simmons, C.P, Yacoub, S

المساهمون: DUKE-NUS MEDICAL SCHOOL

المصدر: Unpaywall 20201031

مصطلحات موضوعية: alanine aminotransferase, aspartate aminotransferase, methylprednisolone, nonstructural protein 1, phenobarbital, prednisolone, adult, anorexia, case report, clinical article, computer assisted tomography, dengue, encephalitis, encephalomyelitis, female, fever, gaze paralysis, Glasgow coma scale, hemiplegia, human, Letter, middle aged, myalgia, nuclear magnetic resonance imaging, pleocytosis, posterior reversible encephalopathy syndrome, seizure, Viet Nam, complication, diagnostic imaging

الوصف: 10.3201/eid2402.171634 ; Emerging Infectious Diseases ; 24 ; 2 ; 402-404

العلاقة: Mai, N.T.H, Phu, N.H, Nghia, H.D.T, Phuong, T.M, Duc, D.T, Chau, N.V.V, Wills, B, Lim, C.C.T, Thwaites, G, Simmons, C.P, Yacoub, S (2018). Dengue-associated posterior reversible encephalopathy syndrome, Vietnam. Emerging Infectious Diseases 24 (2) : 402-404. ScholarBank@NUS Repository. https://doi.org/10.3201/eid2402.171634Test; https://scholarbank.nus.edu.sg/handle/10635/179053Test

الإتاحة: https://doi.org/10.3201/eid2402.171634Test
https://scholarbank.nus.edu.sg/handle/10635/179053Test

المؤلفون: ten Ham, R.M., Hovels, A.M., Hoekman, J., Broekmans, A., Leufkens, H.G., Klungel, O.

المساهمون: Afd Pharmacoepi & Clinical Pharmacology, Innovation and Sustainability, Innovation Studies, PECP - Centre for Pharmacoepidemiology, PECP - Centre for Pharmaceutical Policy and Regulation

مصطلحات موضوعية: adult, conference abstract, content analysis, controlled study, developmental stage, Europe, female, funding, gene therapy, genetic transcription, human, investment, male, market, phase 1 clinical trial, phase 2 clinical trial, phase 4 clinical trial, prediction, reimbursement, semi structured interview, skill, Taverne

الوصف: Objectives: Advanced Therapy Medicinal Product (ATMPs) hold great promise as treatments for previously incurable diseases. While expectations are high and full pipelines are observed, few ATMPs are currently on the EU market. This study aimed to identify root-causes of challenges experienced in achieving successful market access (MA) for commercially developed ATMPs in Europe. Methods: We completed a qualitative case study by conducting 10 semi-structured interviews amongst ATMP company representatives. MA success was defined as receiving reimbursement for an authorized product in at least one Member State. Company MA actions, strategies, experiences and know-how were questioned, as well as how was dealt with encountered challenges. Developers in the study sample differed in: ATMP type (cell and gene therapies), development stage, (Phase I-II, Phase III, regulatory application, Phase IV, discontinued) and company size (Small-Medium-sized Enterprises (SMEs) and large companies). Interviews were recorded, transcribed and coded. Recurring themes were classified via thematic content analysis. Results: Large companies had more experience developing non-ATMP products, giving them an advantage over SMEs in creating value dossiers and HTA authority contact. Large companies also experienced more financial stability. Therefore, they were able to look ahead, while SMEs were also occupied funding their current development stage. Developers who early on involved MA expertise (in-house or external) and had a detailed business plan from the start, seemed more successful. Respondents mentioned a business plan should at least include: short- and long-term goals, market access strategy and return on investment predictions. Some SMEs partnered with large companies to solve funding issues and utilize expertise. No differences between cell and gene therapies were found. Conclusions: Obtaining market access for ATMP development requires more planning and specialised skills compared to more traditional pharmaceutical development. A MA ...

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/414462Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/414462Test

المؤلفون: Kanwugu, O. N., Adadi, P.

المصدر: J. Med. Virol. ; Journal of Medical Virology

مصطلحات موضوعية: ANTIRETROVIRAL THERAPY/COINFECTION, COVID-19, HIV, IMMUNODEFICIENCY, CLINICAL FEATURE, COMORBIDITY, CORONAVIRUS DISEASE 2019, DISEASE ASSOCIATION, DISEASE SEVERITY, HIGH INCOME COUNTRY, HUMAN, HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION, INFECTION RISK, MIXED INFECTION, NONHUMAN, PANDEMIC, REVIEW, VIRUS LOAD, ADULT, CD4+ T LYMPHOCYTE, DIABETES MELLITUS, DRUG EFFECT, FEMALE, GROWTH, DEVELOPMENT AND AGING, HIGHLY ACTIVE ANTIRETROVIRAL THERAPY, HUMAN IMMUNODEFICIENCY VIRUS, HUMAN IMMUNODEFICIENCY VIRUS INFECTION, HYPERTENSION, IMMUNOCOMPROMISED PATIENT

الوصف: Since its first appearance in Wuhan, China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread throughout the world and has become a global pandemic. Several medical comorbidities have been identified as risk factors for coronavirus disease 2019 (COVID-19). However, it remains unclear whether people living with human immunodefeciency virus (PLWH) are at an increased risk of COVID-19 and severe disease manifestation, with controversial suggestion that HIV-infected individuals could be protected from severe COVID-19 by means of antiretroviral therapy or HIV-related immunosuppression. Several cases of coinfection with HIV and SARS-CoV-2 have been reported from different parts of the globe. This review seeks to provide a holistic overview of SARS-CoV-2 infection in PLWH. © 2020 Wiley Periodicals LLC

وصف الملف: application/pdf

العلاقة: Kanwugu O. N. HIV/SARS-CoV-2 coinfection: A global perspective / O. N. Kanwugu, P. Adadi. — DOI 10.1002/jmv.26321 // Journal of Medical Virology. — 2021. — Vol. 93. — Iss. 2. — P. 726-732.; 1466615; Final; All Open Access, Bronze, Green; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088583592&doi=10.1002%2fjmv.26321&partnerID=40&md5=9f4a9266fa950cc756211f3199df34acTest; http://elar.urfu.ru/handle/10995/101482Test; 85088583592; 000552989400001

الإتاحة: https://doi.org/10.1002/jmv.26321Test
http://elar.urfu.ru/handle/10995/101482Test

المؤلفون: Bisgaard Jörgensen, Line, Bastholt, Lars, Yderstraede, Knud

المصدر: Ugeskrift for Laeger. 180(2):132

المؤلفون: Lind, Ann-Marie, Sundlöf, Sofia

مصطلحات موضوعية: Diabetes mellitus type 1, adult, quality of life, dietary carbohydrates, carbohydrates., Diabetes mellitus typ 1, vuxna, livskvalitet, kolhydrater i kosten, kolhydrater.

الوصف: Background: Type 1 Diabetes is a disease that is present in all ages. A treatment with carbohydrate counting and flexible insulin dosing provides a freer diet and is used today in much of the world. Carbohydrate counting with flexible insulin dosing can improve the quality of life in people with diabetes. With support and training the nurse has an important role to support people in their self-care. Aim: To describe how adults with type 1 diabetes mellitus rated and felt their quality of life when using carbohydrate calculated insulin dose and to describe included studies' data collection methods. Method: Descriptive literature review of 13 articles. Literature searches were made in the databases PubMed and CINAHL. Main results: After participating in a structured training regarding carbohydrate counting with flexible insulin dosing rated and experienced the adults with type 1 diabetes, an increased quality of life with greater freedom to customize their diet according to their life situation. Their knowledge of diabetes increased, which gave them a better self-control and self-esteem leading to better self-care. The number of severe hypoglycemia and the fear of them decreased with a carbohydrate calculated insulin dose. Articles used validated questionnaires as data collection methods. Conclusion: Adults with type 1 diabetes, who participated in a structured education in carbohydrate counting with flexible insulin dosing increased their quality of life in both the short and long term and got a better understanding of the disease that gave better self-control and self-esteem leading to better self-care.
Bakgrund: Diabetes mellitus typ 1 är en sjukdom som finns i alla åldrar. En behandlingsmetod med kolhydraträkning och flexibel insulindosering ger en friare kosthållning och används idag i en stor del av världen. Kolhydraträkning med flexibel insulindosering kan förbättra livskvaliteten hos personer med diabetes. Med stöd och utbildning inom området har sjuksköterskan en viktig uppgift att stötta personerna i deras egenvård. Syfte: Att beskriva hur vuxna med diabetes mellitus typ 1 skattade och upplevde sin livskvalitet vid kolhydratberäknad insulindosering samt att beskriva inkluderade studiers datainsamlingsmetoder. Metod: Deskriptiv litteraturstudie av 13 artiklar. Litteratursökningar gjordes i databaserna PubMed och Cinahl. Huvudresultat: Efter deltagande i en strukturerad utbildning i kolhydraträkning med flexibel insulindosering skattade och upplevde vuxna med diabetes mellitus typ 1 en ökad livskvalitet med en ökad frihet att anpassa sin kost efter sin livssituation. Deras kunskaper om diabetessjukdomen ökade vilket gav dem en bättre självkontroll och självkänsla vilket ledde till bättre egenvård. Antalet svåra hypoglykemier och rädslan för dessa minskade med en kolhydratberäknad insulindosering. Artiklarna använde validerade frågeformulär som datainsamlingsmetod. Slutsats: Vuxna med diabetes mellitus typ 1 som deltagit i en strukturerad utbildning i kolhydraträkning med flexibel insulindosering ökade sin livskvalitet både på kort och lång sikt samt fick bättre kunskap om sjukdomen som gav bättre självkontroll och självkänsla vilket ledde till bättre egenvård.

وصف الملف: application/pdf

الإتاحة: http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-21852Test

المؤلفون: Eduardo de Paula Miranda

مرشدي الرسالة: Ricardo Jordão Duarte, Katia Ramos Moreira Leite, Marcelo Lopes de Lima, Roberto Iglesias Lopes

المصدر: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

مصطلحات موضوعية: Adulto, Antígeno CA-19- 9, Curva ROC, Diagnóstico, Hidronefrose, Lipocalinas, Marcadores biológicos, Microglobulina-2 beta, Molécula de lesão renal tipo 1, Obstrução ureteral, Adult, Beta 2-microglobulin, Biological markers, CA-19-9 antigen, Diagnosis, Hydronephrosis, Kidney injury molecule-1, Lipocalins, ROC curve, Ureteral obstruction

الوصف: INTRODUÇÃO E OBJETIVO: A estenose de junção ureteropélvica (EJUP) é importante causa de obstrução do trato urinário e pode levar a deterioração progressiva da função renal. Há espaço para o aprimoramento de novos métodos diagnósticos capazes de discriminar hidronefrose e uropatia obstrutiva. Acredita-se que os biomarcadores urinários podem fornecer indícios de lesão renal precoce na obstrução urinária. Neste contexto, KIM-1 pode elevar-se na urina por lesão tubular proximal, NGAL por lesão no túbulo proximal, distal ou alça de Henle, CA19-9 por produção excessiva no túbulo obstruído e ?2-microglobulina (beta2M) por injúria ao glomérulo ou ao túbulo proximal. O objetivo do presente estudo foi avaliar as propriedades diagnósticas dos biomarcadores urinários citados em adultos com EJUP, sendo o primeiro estudo na literatura a avaliar tais moléculas nesta população. MÉTODOS: Foram estudados de modo prospectivo pacientes consecutivos acima de 18 anos com diagnóstico de EJUP submetidos a pieloplastia videolaparoscópica de dezembro de 2013 a fevereiro de 2015. Foram excluídos do estudo pacientes com EJUP bilateral, rim contralateral patológico, EJUP em rim único, antecedentes de tratamento cirúrgico para estenose de JUP ou taxa de filtração glomerular inferior a 60 ml/min/1,73m2. Cada paciente forneceu quatro amostras de urina para medição de biomarcadores, uma no pré-operatório e outras com 1, 3 e 6 meses de seguimento pós-operatório. O grupo controle foi constituído por voluntários saudáveis sem hidronefrose à ultrassonografia. RESULTADOS: Foram incluídos 47 pacientes com idade média de 38,6 ± 12,7 anos (intervalo 19 a 64 anos), sendo 17 (36,2%) do sexo masculino e 30 (62,8%) do sexo feminino. O grupo controle foi composto por 40 indivíduos semelhantes ao grupo com EJUP no que concerne idade (p = 0,95) e sexo (p = 0,82). KIM-1 foi o marcador com melhores propriedades diagnósticas, apresentando área sob a curva (AUC) de 0,79 (95% CI 0,70 a 0,89). O NGAL, por sua vez, teve AUC de 0,71 (95% CI 0,61 a 0,83), CA19- 9 teve AUC de 0,70 (95% CI 0,60 a 0,81) e (beta2M) apresentou AUC de 0,61 (95% CI 0,50 a 0,73), sendo o único biomarcador com propriedades inadequadas neste cenário. O KIM-1 foi o marcador mais sensível com o ponto de corte 170,4 pg/mg de creatinina (sensibilidade 91,4%, especificidade 59,1%) e o CA 19-9 o mais específico para o ponto de corte de 51,3 U/mg de creatinina (sensibilidade 48,9%, especificidade 88,0%), enquanto o NGAL foi o que apresentou maior queda após desobstrução, com 90,0% dos pacientes apresentando clareamento superior a 50%. CONCLUSÕES: A avaliação dos biomarcadores urinários é útil no diagnóstico de obstrução em adultos com EJUP submetidos a pieloplastia videolaparoscópica. O KIM-1 foi o marcador mais sensível e o CA 19-9 o mais específico, enquanto o NGAL foi o que apresentou maior que com a desobstrução. Houve queda das concentrações dos marcadores após pieloplastia no período estudado. O papel exato dos biomarcadores urinários no cenário de obstrução em adultos deve ser mais amplamente investigado
INTRODUCTION AND OBJECTIVE: Ureteropelvic junction obstruction (UPJO) is an important cause of urinary tract obstruction and can lead to progressive deterioration of renal function. Thus the development of novel non-invasive methods capable of discriminating obstruction and hydronephrosis may be useful. Elevation of urinary biomarkers may provide early evidence of kidney damage in urinary obstruction. In this scenario, urinary concentrations of KIM-1 may be elevated following proximal tubular injury, while NGAL may increase as result of injury to proximal or distal tubule as well as to loop of Henle, CA19-9 after overproduction in the obstructed tubule and ?2 microglobulin (beta2M) after injury to the glomerulus or the proximal tubule. The aim of this study was to evaluate the diagnostic properties of these urinary biomarkers in adults with UPJO. METHODS: We prospectively studied consecutive patients older than 18 years diagnosed with UPJO undergoing laparoscopic pyeloplasty from December 2013 to February 2015 in our institution. Exclusion criteria included patients with bilateral UPJO, unilateral UPJO with contralateral pathologic kidney, solitary kidney, history of previous surgical treatment for UPJO or glomerular filtration rate below 60 ml/min/1,73m2. Each patient provided four voided urine samples for biomarker measurement, one at preoperative consultation and the others at 1, 3 and 6 months of postoperative follow-up. Healthy individuals with no hydronephrosis on ultrasound evaluation constituted our control group. RESULTS: We included 47 patients with a mean age of 38.6 ± 12.7 years (range 19-64 years), from which 17 (36.2%) were males and 30 (62.8%) were females. The control group consisted of 40 subjects with no statistical difference to the study group regarding age (p = 0.95) and gender (p = 0.82). KIM-1 had an area under the curve (AUC) of 0.79 (95% CI 0.70 to 0.89) and was the biomarker with the best diagnostic properties. CA19-9 had an AUC of 0.70 (95% CI 0.60 to 0.81), NGAL had an AUC of 0.71 (95% CI 0.61 to 0.83) and beta2M had an AUC of 0.61 (95% CI 0.50 to 0.73). KIM-1 was the most sensitive marker with a cutoff of 170.4 pg/mg creatinine (sensitivity 91.4%, specificity 59.1%) whereas CA 19-9 as the most specific one, displaying a cutoff of 51.3 U/mg creatinine (sensitivity 48.9%, specificity 88.0%). NGAL showed the greatest decrease in urinary concentrations after pyeloplasty, in which 90.0% of patients had a clearance greater than 50% in comparison to preoperative values. CONCLUSIONS: The evaluation of urinary biomarkers is useful in the assessment of UPJO in adults undergoing laparoscopic pyeloplasty. Urinary concentrations of CA 19-9, NGAL and KIM-1 were elevated in patients with UPJO and significantly decreased after pyeloplasty. The exact role of those biomarkers in the setting of obstruction in adults should be further evaluated

الإتاحة: http://www.teses.usp.br/teses/disponiveis/5/5153/tde-20052016-160232Test/