دورية أكاديمية
Genome-wide DNA methylation profiling of blood from monozygotic twins discordant for myocardial infarction
| العنوان: | Genome-wide DNA methylation profiling of blood from monozygotic twins discordant for myocardial infarction |
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| المؤلفون: | Köseler, Aylin, Ma, F., Kılıç, Ä°smail DoÄŸu, Morselli, M., Kilic, O., Pellegrini, M. |
| بيانات النشر: | International Institute of Anticancer Research |
| سنة النشر: | 2020 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | acyl coenzyme A synthetase medium chain family member 5, AFG3 like matrix AAA peptidase subunit 2, apolipoprotein B, aspartate aminotransferase, Humans, Male, Myocardial Infarction, Phenotype, Prognosis, Promoter Regions, Genetic, Twins, Monozygotic, Cardiovascular disease, DNA methylation, Epigenetics, acyl coenzyme A synthetase family member 3, acyl coenzyme A synthetase medium chain family member 2A, carboxylesterase 1, carboxylesterase 1 pseudogene 1, creatine kinase, enzyme, genomic DNA, hydrolase, iron sulfur cluster assembly enzyme, lactate dehydrogenase, lipid droplet associated hydrolase, microsomal triglyceride transfer protein, SEC14 like lipid binding 2, unclassified drug |
| الوصف: | Background/Aim: This study aimed to measure the DNA methylation state of thousands of CpG islands in the blood of two monozygotic twins that were discordant for cardiovascular disease (CVD). Twin 1 had suffered myocardial infarction, while the other was healthy. Patients and Methods: Since the aim of this study was to identify differentially methylated regions which might act as potential markers, reduced-representation bisulfite libraries were used for whole-genome methylation analysis. Results: According to the analysis, 11 genes lipid droplet associated hydrolase (LDAH), apolipoprotein B (APOB), acyl-CoA synthetase medium chain family member 2A (ACSM2A), acyl-CoA synthetase medium chain family member 5(ACSM5), acyl-CoA synthetase family member 3 (ACSF3), carboxylesterase 1 (CES1), carboxylesterase 1 pseudogene 1 (CES1P1), AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), iron-sulfur cluster assembly enzyme (ISCU), SEC14 like lipid binding 2 (SEC14L2) and microsomal triglyceride transfer protein (MTTP) were all hypomethylated in DNA from twin 2, the unaffected twin. Methylation changes were observed at different multiple loci between the twins, suggesting loci that are affected by disease status in identical genetic backgrounds. Conclusion: This twin study may contribute significantly to the understanding of the genetic basis of CVD and resulting myocardial infarction. This approach may allow identification of possible target loci associated with aberrant epigenetic regulation in CVD. © 2020 International Institute of Anticancer Research. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0258-851X |
| العلاقة: | In Vivo; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/37524Test; https://doi.org/10.21873/invivo.11782Test; 34; 361; 367; 2-s2.0-85077264159; WOS:000504753200044 |
| DOI: | 10.21873/invivo.11782 |
| الإتاحة: | https://doi.org/10.21873/invivo.11782Test https://hdl.handle.net/11499/37524Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.3FED6639 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0258851X |
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| DOI: | 10.21873/invivo.11782 |