دورية أكاديمية
The Cost-Effectiveness of Vaccination of Older Adults with an MF59-Adjuvanted Quadrivalent Influenza Vaccine Compared to Other Available Quadrivalent Vaccines in Germany
| العنوان: | The Cost-Effectiveness of Vaccination of Older Adults with an MF59-Adjuvanted Quadrivalent Influenza Vaccine Compared to Other Available Quadrivalent Vaccines in Germany |
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| المؤلفون: | Michele A. Kohli, Michael Maschio, Shannon Cartier, Joaquin Mould-Quevedo, Frank-Ulrich Fricke |
| المصدر: | Vaccines, Vol 10, Iss 9, p 1386 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | MF59-adjuvanted trivalent influenza vaccine, aTIV, high-dose trivalent influenza vaccine, TIV-HD, MF59-adjuvanted quadrivalent influenza vaccine, aQIV, Medicine |
| الوصف: | Enhanced quadrivalent influenza vaccines that include an adjuvant (aQIV) or a high dose of antigen (QIV-HD), which stimulate a stronger immune response in older adults than the standard vaccine (QIVe), are now approved. The objective of this research is to compare available vaccines and determine the cost-effectiveness of immunizing persons aged 65 years and above with aQIV compared to QIVe and QIV-HD in Germany. A compartmental transmission model calibrated to outpatient visits for influenza in Germany was used to predict the number of medically attended infections using the three vaccines. The rates of hospitalizations, deaths, and other economic consequences were estimated with a decision tree using German data where available. Based on meta-analysis, the rVE of −2.5% to 8.9% for aQIV versus QIV-HD, the vaccines are similar clinically, but aQIV is cost saving compared to QIV-HD (unit cost of EUR 40.55). All results were most sensitive to changes in vaccine effectiveness. aQIV may be cost-effective compared to QIVe depending on the willingness to pay for additional benefits in Germany. As aQIV and QIV-HD are similar in terms of effectiveness, aQIV is cost saving compared to QIV-HD at current unit prices. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 10091386 2076-393X |
| العلاقة: | https://www.mdpi.com/2076-393X/10/9/1386Test; https://doaj.org/toc/2076-393XTest |
| DOI: | 10.3390/vaccines10091386 |
| الوصول الحر: | https://doaj.org/article/eb1c4498194a4a01be14f34440de196fTest |
| رقم الانضمام: | edsdoj.b1c4498194a4a01be14f34440de196f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10091386 2076393X |
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| DOI: | 10.3390/vaccines10091386 |