التفاصيل البيبلوغرافية
| العنوان: |
EXPERIMENTAL STUDY Functional in vitro studies on the role and regulation of interleukin-6 in human somatotroph pituitary adenomas |
| المؤلفون: |
Jan-oliver Thiele, Penny Lohrer, Ludwig Schaaf, Manuela Feirer, Walter Stummer, Marco Losa, Manfred Lange, Maria Tichomirowa, Eduardo Arzt, Günter K Stalla, Ulrich Renner |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://www.eje-online.org/content/149/5/455.full.pdfTest. |
| المجموعة: |
CiteSeerX |
| الوصف: |
Objective: Interleukin-6 (IL-6), a member of the gp130 cytokine family, is considered to be an important modulator of function and growth in endocrine anterior pituitary cells. In pituitary adenomas, where IL-6 is often produced by the tumour cells, it is thought to be involved in pituitary adenoma pathophysiology via autocrine/paracrine mechanisms. Methods: We have studied in primary cell cultures of human somatotroph adenomas whether IL-6 stimulates growth hormone secretion and whether intratumoral IL-6 is affected by various IL-6-regulating factors. Results: Interleukin-6 stimulated GH secretion in 10 out of 11 somatotroph adenoma cultures (1.4- to 6.5-fold above basal levels). In comparative studies the GH-stimulatory potency of IL-6 was identical, or even stronger, than that of GHRH. In eight out of 11 adenoma cell cultures, IL-6 production was observed. This suggests that GH production might be stimulated by IL-6 in an autocrine/paracrine manner in these tumours. Dexamethasone strongly inhibited basal IL-6 secretion in all IL-6-producing adenoma cell cultures, whereas the IL-6 inhibitory or stimulatory action of other factors (octreotide, transforming growth factor-b1, insulin-like growth factor-I, pituitary adenylate cyclase-activating |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.2965Test; http://www.eje-online.org/content/149/5/455.full.pdfTest |
| الإتاحة: |
http://www.eje-online.org/content/149/5/455.full.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.B3282C8F |
| قاعدة البيانات: |
BASE |
