دورية أكاديمية
Regulation of ER-phagy by a Ypt/Rab GTPase module
| العنوان: | Regulation of ER-phagy by a Ypt/Rab GTPase module |
|---|---|
| المؤلفون: | Zhanna Lipatova, Ankur H. Shah, Jane J. Kim, Jonathan W. Mulholland, Nava Segev |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | untagged |
| الوصف: | Accumulation of misfolded proteins on intracellular membranes has been implicated in neurodegenerative diseases. One cellular pathway that clears such aggregates is endoplasmic reticulum autophagy (ER-phagy), a selective autophagy pathway that delivers excess ER to the lysosome for degradation. Not much is known about the regulation of ER-phagy. The conserved Ypt/Rab GTPases regulate all membrane trafficking events in eukaryotic cells. We recently showed that a Ypt module, consisting of Ypt1 and autophagy-specific upstream activator and downstream effector, regulates the onset of selective autophagy in yeast. Here we show that this module acts at the ER. Autophagy-specific mutations in its components cause accumulation of excess membrane proteins on aberrant ER structures and induction of ER stress. This accumulation is due to a block in transport of these membranes to the lysosome, where they are normally cleared. These findings establish a role for an autophagy-specific Ypt1 module in the regulation of ER-phagy. Moreover, because Ypt1 is a known key regulator of ER-to-Golgi transport, these findings establish a second role for Ypt1 at the ER. We therefore propose that individual Ypt/Rabs, in the context of distinct modules, can coordinate alternative trafficking steps from one cellular compartment to different destinations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | http://hdl.handle.net/10027/11182Test; https://figshare.com/articles/journal_contribution/Regulation_of_ER-phagy_by_a_Ypt_Rab_GTPase_module/10777607Test |
| الإتاحة: | http://hdl.handle.net/10027/11182Test https://figshare.com/articles/journal_contribution/Regulation_of_ER-phagy_by_a_Ypt_Rab_GTPase_module/10777607Test |
| حقوق: | In Copyright |
| رقم الانضمام: | edsbas.92A82D7A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |