دورية أكاديمية

Simultaneous Subconjunctival Triamcinolone and Bevacizumab Injections for Management of Blepharokeratoconjunctivitis in Children

التفاصيل البيبلوغرافية
العنوان: Simultaneous Subconjunctival Triamcinolone and Bevacizumab Injections for Management of Blepharokeratoconjunctivitis in Children
المؤلفون: Chu Luan Nguyen, Tony S. Chen, Khoi Tran, James E. H. Smith, Noni Lewis
المصدر: Case Reports in Ophthalmological Medicine, Vol 2018 (2018)
بيانات النشر: Hindawi Limited, 2018.
سنة النشر: 2018
المجموعة: LCC:Ophthalmology
مصطلحات موضوعية: Ophthalmology, RE1-994
الوصف: Purpose. To report the efficacy of subconjunctival triamcinolone (Kenalog A-40, Alcon) and bevacizumab (Avastin, Genentech) injections in fraternal twins with blepharokeratoconjunctivitis (BKC) causing progressive, bilateral corneal neovascularization and scarring. Methods. In this retrospective observational case series, two three-year-old male twins with BKC had presented with bilateral red eyes, photophobia, and frequent blinking. Examination of each child showed bilateral deep stromal and superficial corneal neovascularization, corneal infiltrates, multiple follicles on the palpebral conjunctiva bilaterally with blepharitis, and thick turbid sebum expressed from the Meibomian glands. Their disease progressed despite conventional treatment. Both twins were managed with subconjunctival triamcinolone injection and subconjunctival bevacizumab injection of each eye. Results. The treatment resulted in improvement of symptoms, and examination over an 8-10-month period postinjections showed fading stromal corneal infiltrates, partially regressed corneal neovascularization, and reduced conjunctival injection without complications. Conclusion. This case series highlights the potential vision threatening complications of BKC. In addition to conventional management options, this report is the first published use of subconjunctival triamcinolone and bevacizumab injections for BKC in children in an attempt to minimize and improve corneal neovascularization and scarring and subsequently to retain useful vision.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2090-6722
2090-6730
العلاقة: https://doaj.org/toc/2090-6722Test; https://doaj.org/toc/2090-6730Test
DOI: 10.1155/2018/2602487
الوصول الحر: https://doaj.org/article/a24a9bc03aac42b3a6f0e6090d542addTest
رقم الانضمام: edsdoj.24a9bc03aac42b3a6f0e6090d542add
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20906722
20906730
DOI:10.1155/2018/2602487