دورية أكاديمية
Immune phenotypes predict survival in patients with glioblastoma multiforme
| العنوان: | Immune phenotypes predict survival in patients with glioblastoma multiforme |
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| المؤلفون: | Haouraa Mostafa, Andrej Pala, Josef Högel, Michal Hlavac, Elvira Dietrich, M. Andrew Westhoff, Lisa Nonnenmacher, Timo Burster, Michael Georgieff, C. Rainer Wirtz, E. Marion Schneider |
| المصدر: | Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-14 (2016) |
| بيانات النشر: | BMC, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Glioblastoma multiforme, CD8+ lymphocytes, NK cells, CD39-ectonucleotidase, Recursive partitioning analysis, Survival, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Background Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The current study aimed at the analysis of immunological control in individual patients with GBM. Methods Immune phenotypes and plasma biomarkers of GBM patients were determined at the time of diagnosis using flow cytometry and ELISA, respectively. Results Using descriptive statistics, we found that immune anomalies were distinct in individual patients. Defined marker profiles proved highly relevant for survival. A remarkable relation between activated NK cells and improved survival in GBM patients was in contrast to increased CD39 and IL-10 in patients with a detrimental course and very short survival. Recursive partitioning analysis (RPA) and Cox proportional hazards models substantiated the relevance of absolute numbers of CD8 cells and low numbers of CD39 cells for better survival. Conclusions Defined alterations of the immune system may guide the course of disease in patients with GBM and may be prognostically valuable for longitudinal studies or can be applied for immune intervention. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-8722 |
| العلاقة: | http://link.springer.com/article/10.1186/s13045-016-0272-3Test; https://doaj.org/toc/1756-8722Test |
| DOI: | 10.1186/s13045-016-0272-3 |
| الوصول الحر: | https://doaj.org/article/1a4e2613937a445a9aeffa4b5717cd6aTest |
| رقم الانضمام: | edsdoj.1a4e2613937a445a9aeffa4b5717cd6a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17568722 |
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| DOI: | 10.1186/s13045-016-0272-3 |