المؤلفون: Rytting, Michael E, Thomas, Deborah A, O'Brien, Susan M, Ravandi‐Kashani, Farhad, Jabbour, Elias J, Franklin, Anna R, Kadia, Tapan M, Pemmaraju, Naveen, Daver, Naval G, Ferrajoli, Alessandra, Garcia‐Manero, Guillermo, Konopleva, Marina Y, Cortes, Jorge E, Borthakur, Gautham, Garris, Rebecca, Cardenas‐Turanzas, Maria, Schroeder, Kurt, Jorgensen, Jeffrey L, Kornblau, Steven M, Kantarjian, Hagop M

المصدر: Cancer. 120(23)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Childhood Leukemia, Stem Cell Research, Pediatric Cancer, Pediatric Research Initiative, Pediatric, Orphan Drug, Rare Diseases, Cancer, Hematology, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, Asparaginase, Cohort Studies, Consolidation Chemotherapy, Cyclophosphamide, Cytarabine, Daunorubicin, Dexamethasone, Doxorubicin, Female, Humans, Induction Chemotherapy, Maintenance Chemotherapy, Male, Mercaptopurine, Methotrexate, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prospective Studies, Thioguanine, Treatment Outcome, Vincristine, Young Adult, Philadelphia chromosome-negative ALL, acute lymphoblastic leukemia, augmented Berlin-Frankfurt-Münster, pediatric-based regimens, pediatric-based therapy, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Public health

الوصف: BackgroundVarious trials have reported improved outcomes for adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) who received treatment with pediatric-based regimens. Those reports prompted the current investigation of the pediatric augmented Berlin-Frankfurt-Münster (ABFM) regimen in AYA patients. The results were compared with those from a similar population that received the hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) regimen.MethodsEighty-five patients ages 12 to 40 years who had Philadelphia chromosome (Ph)-negative ALL received the ABFM regimen from October 2006 through April 2012. Their outcome was compared with outcomes in 71 historic AYA patients who received hyper-CVAD from the authors' institution. Patient and disease characteristics, as well as minimal residual disease status, were analyzed for their impact on outcomes.ResultsThe complete response rate with ABFM was 94%. The 3-year complete remission duration (CRD) and overall survival (OS) rates were 70% and 74%, respectively. For patients aged ≤21 years, the 3-year CRD and OS rates were 72% and 85%, respectively; and, for patients ages 21 to 40 years, the respective rates were 69% and 60%. The initial white blood cell count was an independent predictive factor of OS and CRD. The minimal residual disease status on days 29 and 84 of therapy also were predictive of long-term outcomes. Severe regimen toxicities included transient hepatotoxicity in 35% to 39% of patients, pancreatitis in 11% of patients, osteonecrosis in 11% of patients, and thrombosis in 22% of patients. The 3-year OS rate was 74% in the ABFM group versus 71% in the hyper-CVAD group, and the corresponding 3-year CRD rate was 70% versus 66%, respectively.ConclusionsABFM was tolerable in AYA patients with ALL but was not associated with significant improvements in CRD and OS compared with hyper-CVAD.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8xj1p2qzTest

المؤلفون: Harding, Richard, Marchetti, Stefano, Onwuteaka-Philipsen, Bregje D., Wilson, Donna M., Ruiz-Ramos, Miguel, Cardenas-Turanzas, Maria, Rhee, YongJoo, Morin, Lucas, Hunt, Katherine, Teno, Joan, Hakanson, Cecilia, Houttekier, Dirk, Deliens, Luc, Cohen, Joachim

المصدر: Harding , R , Marchetti , S , Onwuteaka-Philipsen , B D , Wilson , D M , Ruiz-Ramos , M , Cardenas-Turanzas , M , Rhee , Y , Morin , L , Hunt , K , Teno , J , Hakanson , C , Houttekier , D , Deliens , L & Cohen , J 2018 , ' Place of death for people with HIV: A population-level comparison of eleven countries across three continents using death certificate data ' , BMC Infectious Diseases , vol. 18 , no. 1 , 55 . https://doi.org/10.1186/s12879-018-2951-xTest

الوصف: Background: With over 1 million HIV-related deaths annually, quality end-of-life care remains a priority. Given strong public preference for home death, place of death is an important consideration for quality care. This 11 country study aimed to i) describe the number, proportion of all deaths, and demographics of HIV-related deaths; ii) identify place of death; iii) compare place of death to cancer patients iv), determine patient/health system factors associated with place of HIV-related death. Methods: In this retrospective analysis of death certification, data were extracted for the full population (ICD-10 codes B20-B24) for 1-year period: deceased's demographic characteristics, place of death, healthcare supply. Results: i) 19,739 deaths were attributed to HIV. The highest proportion (per 1000 deaths) was for Mexico (9.8%), and the lowest Sweden (0.2%). The majority of deaths were among men (75%), and those aged <50 (69.1%). ii) Hospital was most common place of death in all countries: from 56.6% in the Netherlands to 90.9% in South Korea. The least common places were hospice facility (3.3%-5.7%), nursing home (0%-17.6%) and home (5.9%-26.3%).iii) Age-standardised relative risks found those with HIV less likely to die at home and more likely to die in hospital compared with cancer patients, and in most countries more likely to die in a nursing home. iv) Multivariate analysis found that men were more likely to die at home in UK, Canada, USA and Mexico; a greater number of hospital beds reduced the likelihood of dying at home in Italy and Mexico; a higher number of GPs was associated with home death in Italy and Mexico. Conclusions: With increasing comorbidity among people ageing with HIV, it is essential that end-of-life preferences are established and met. Differences in place of death according to country and diagnosis demonstrate the importance of ensuring a "good death" for people with HIV, alongside efforts to optimise treatment.

العلاقة: https://research.vumc.nl/en/publications/865176cc-2a71-4b26-af8a-2c303e0f9d83Test

الإتاحة: https://doi.org/10.1186/s12879-018-2951-xTest
https://research.vumc.nl/en/publications/865176cc-2a71-4b26-af8a-2c303e0f9d83Test
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85041455017&origin=inwardTest
https://www.ncbi.nlm.nih.gov/pubmed/29370765Test