التفاصيل البيبلوغرافية
| العنوان: |
Understanding the Philosophy, Anatomy, and Surgery of the Extra-TME Plane of Locally Advanced and Locally Recurrent Rectal Cancer; Single Institution Experience with International Benchmarking. |
| المؤلفون: |
van Kessel, Charlotte S.1,2 (AUTHOR), Solomon, Michael J.1,2,3,4 (AUTHOR) professor.solomon@sydney.edu.au |
| المصدر: |
Cancers. Oct2022, Vol. 14 Issue 20, p5058-N.PAG. 15p. |
| مصطلحات موضوعية: |
*SURGICAL therapeutics, *PELVIC exenteration, *CANCER chemotherapy, *CANCER relapse, *SURVIVAL analysis (Biometry), *PHILOSOPHY, *COMBINED modality therapy, RECTUM tumors |
| مستخلص: |
Simple Summary: Worldwide there is still unwarranted variation in peri-operative management and subsequently oncological outcome following pelvic exenteration for locally advanced and recurrent rectal cancer. The major contributing factor seems to be a difference in treatment strategy with many centres aiming for more neoadjuvant treatment and less radical surgery. However, a radical resection with clear operative margins remains the single most important prognostic factor for survival and therefore an aggressive, radical approach is justified for an optimal oncological outcome and remains the gold standard of care. Pelvic exenteration surgery has become a widely accepted procedure for treatment of locally advanced (LARC) and locally recurrent rectal cancer (LRRC). However, there is still unwarranted variation in peri-operative management and subsequently oncological outcome after this procedure. In this article we will elaborate on the various reasons for the observed differences based on benchmarking results of our own data to the data from the PelvEx collaborative as well as findings from 2 other benchmarking studies. Our main observation was a significant difference in extent of resection between exenteration units, with our unit performing more complete soft tissue exenterations, sacrectomies and extended lateral compartment resections than most other units, resulting in a higher R0 rate and longer overall survival. Secondly, current literature shows there is a tendency to use more neoadjuvant treatment such as re-irradiation and total neoadjuvant treatment and perform less radical surgery. However, peri-operative chemotherapy or radiotherapy should not be a substitute for adequate radical surgery and an R0 resection remains the gold standard. Finally, we describe our experiences with standardizing our surgical approaches to the various compartments and the achieved oncological and functional outcomes. [ABSTRACT FROM AUTHOR] |
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