دورية أكاديمية
Macrophages and fibrosis in adipose tissue are linked to liver damage and metabolic risk in obese children
| العنوان: | Macrophages and fibrosis in adipose tissue are linked to liver damage and metabolic risk in obese children |
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| المؤلفون: | Walker RW, Allayee H, Inserra A, Fruhwirth R, Alisi A, Devito R, Carey ME, Sinatra F, Goran MI, Nobili V. |
| المساهمون: | Walker, Rw, Allayee, H, Inserra, A, Fruhwirth, R, Alisi, A, Devito, R, Carey, Me, Sinatra, F, Goran, Mi, Nobili, V. |
| بيانات النشر: | Nature Publishing Group ;Houndmills |
| سنة النشر: | 2014 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | Adiponectin, Adiposity, Adolescent, Alanine Transaminase, Aspartate Aminotransferase, Biomarker, Blood Glucose, Body Height, Body Mass Index, Body Weight, C-Reactive Protein, Child, Diabetes Mellitus, Type 2, Fasting, Female, Human, Insulin, Interleukin-6, Intra-Abdominal Fat, Liver, Liver Cirrhosi, Macrophage, Male, Obesity, Prospective Studie, Risk Factor, Subcutaneous Fat, Abdominal, Tumor Necrosis Factor-alpha |
| الوصف: | Objective Obesity in childhood is associated with an inflammatory state in adipose tissue and liver, which elevates risk for diabetes and liver disease. No prior study has examined associations between pathologies occurring in adipose tissue and liver to identify elements of tissue damage associated with type 2 diabetes risk. This study sought to determine whether inflammation and fibrosis in abdominal subcutaneous adipose tissue (SAT) in obese/overweight children (BMI-z 2.3±0.76) was related to the extent of observed liver disease or type 2 diabetes risk. Methods Biopsy samples of abdominal (SAT) and liver were simultaneously collected from 33 Italian children (mean BMI 28.1±5.1 kg/m2and mean age 11.6±2.2 years) with confirmed NAFLD. Histology and immunohistochemistry were conducted on biopsies to assess inflammation and fibrosis in adipose tissue and fibrosis and inflammation in liver. Results Presence vs. absence of crown-like structures (CLS) in SAT was significantly related to liver fibrosis scores (1.7±0.7 vs. 1.2±0.7, P=0.04) independent of BMI. SAT fibrosis was significantly correlated with a lower disposition index (r=-0.48, P=0.006). No other adipose measures were associated with liver disease parameters. Conclusion Markers of subcutaneous white adipose tissue inflammation are associated with greater extent of liver fibrosis independent of obesity and SAT fibrosis may contribute to diabetes risk through reduced insulin secretion. Copyright © 2014 The Obesity Society. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/24616207; info:eu-repo/semantics/altIdentifier/wos/WOS:000337537000019; volume:22; issue:6; firstpage:1512; lastpage:1519; numberofpages:8; journal:OBESITY; http://hdl.handle.net/11573/1177874Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84901620718 |
| DOI: | 10.1002/oby.20730 |
| الإتاحة: | https://doi.org/10.1002/oby.20730Test http://hdl.handle.net/11573/1177874Test |
| رقم الانضمام: | edsbas.6018F74A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/oby.20730 |
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