دورية أكاديمية
Tumor Suppressive Effects of miR-124 and Its Function in Neuronal Development
| العنوان: | Tumor Suppressive Effects of miR-124 and Its Function in Neuronal Development |
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| المؤلفون: | Rikako Sanuki, Tomonori Yamamura |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 11, p 5919 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | microRNA-124, tumor suppression, EMT, metastasis, neuronal development, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | MicroRNA-124 (miR-124) is strongly expressed in neurons, and its expression increases as neurons mature. Through DNA methylation in the miR-124 promoter region and adsorption of miR-124 by non-coding RNAs, miR-124 expression is known to be reduced in many cancer cells, especially with high malignancy. Recently, numerous studies have focused on miR-124 due to its promising tumor-suppressive effects; however, the overview of their results is unclear. We surveyed the tumor-suppressive effect of miR-124 in glial cell lineage cancers, which are the most frequently reported cancer types involving miR-124, and in lung, colon, liver, stomach, and breast cancers, which are the top five causes of cancer death. Reportedly, miR-124 not only inhibits proliferation and accelerates apoptosis, but also comprehensively suppresses tumor malignant transformation. Moreover, we found that miR-124 exerts its anti-tumor effects by regulating a wide range of target genes, most notably STAT3 and EZH2. In addition, when compared to the original role of miR-124 in neuronal development, we found that the miR-124 target genes that contribute to neuronal maturation share similarities with genes that cause cancer cell metastasis and epithelial-mesenchymal transition. We believe that the two apparently unrelated fields, cancer and neuronal development, can bring new discoveries to each other through the study of miR-124. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 22115919 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/22/11/5919Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms22115919 |
| الوصول الحر: | https://doaj.org/article/37795f9faaaf463782501fe2ddaabc96Test |
| رقم الانضمام: | edsdoj.37795f9faaaf463782501fe2ddaabc96 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22115919 14220067 16616596 |
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| DOI: | 10.3390/ijms22115919 |