دورية أكاديمية
Demographics, phenotypic health characteristics and genetic analysis of centenarians in China
| العنوان: | Demographics, phenotypic health characteristics and genetic analysis of centenarians in China |
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| المؤلفون: | Zeng, Yi, Feng, Qiushi, Gu, Danan, Vaupel, James W. |
| المساهمون: | Zeng, Y (reprint author), Peking Univ, Raissun Inst Adv Studies, Natl Sch Dev, Beijing 200871, Peoples R China., Duke Univ, Sch Med, Ctr Study Aging & Human Dev, Durham, NC 27706 USA., Peking Univ, Raissun Inst Adv Studies, Natl Sch Dev, Ctr Hlth Aging & Dev Studies, Beijing, Peoples R China., Natl Univ Singapore, Dept Sociol, Singapore, Singapore., Natl Univ Singapore, Ctr Family & Populat Res, Singapore, Singapore., United Nations Populat Div, New York, NY USA., Max Planck Inst Demog Res, Rostock, Germany., Peking Univ, Raissun Inst Adv Studies, Natl Sch Dev, Beijing 200871, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | MECHANISMS OF AGEING AND DEVELOPMENT |
| سنة النشر: | 2017 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Centenarians, Healthy longevity, Health phenotypes, Genetic variants, GxE interactions, China, GENOME-WIDE ASSOCIATION, HAN CHINESE, OLDEST-OLD, GENDER DIFFERENTIALS, FUNCTIONAL DECLINE, TEA CONSUMPTION, HUMAN LONGEVITY, FOXO GENOTYPES, ADVANCED AGES, RESILIENCE |
| الوصف: | After a brief introduction to the background, significance and unique features of the centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity Study (CLHLS), which is the world's largest study of centenarians, nonagenarians, octogenarians, and compatible young-old aged 65-79. Based on the CLHLS data and other relevant studies, we summarize demographic and socioeconomic characteristics as well as self-reported and objectively-tested health indicators of centenarians in China, with'an emphasis on gender differences and rural urban disparities. We then compare five-year age-specific trajectories of physical and cognitive functions, self-reported health, and life satisfactions from ages 65-69 to 100+, concluding that good psychological resilience and optimism are keys to the exceptional longevity enjoyed by centenarians. We discuss recent findings of novel loci and pathways that are significantly associated with longevity based on the genome-wide association study (GWAS) of the CLHLS centenarian sample, which is 2.7 times as large as prior GWAS of longevity. We also highlight colleagues' and our own studies on longevity candidate genes and gene-environment interaction analyses. Finally, we discuss limitations inherent in our studies of centenarians in China and further research perspectives. (C) 2016 Elsevier Ireland Ltd. All rights reserved. ; National Natural Science Foundation of China [71233001, 71490732, 71110107025]; US NIA/NIH [R01 AG023627, 2P01AG031719] ; SCI(E) ; SSCI ; ARTICLE ; SI ; 86-97 ; 165 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0047-6374 |
| العلاقة: | MECHANISMS OF AGEING AND DEVELOPMENT.2017,165(,SI),86-97.; 1902961; http://hdl.handle.net/20.500.11897/469082Test; WOS:000411540500006 |
| DOI: | 10.1016/j.mad.2016.12.010 |
| الإتاحة: | https://doi.org/20.500.11897/469082Test https://doi.org/10.1016/j.mad.2016.12.010Test https://hdl.handle.net/20.500.11897/469082Test |
| رقم الانضمام: | edsbas.38EE11E5 |
| قاعدة البيانات: | BASE |
| تدمد: | 00476374 |
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| DOI: | 10.1016/j.mad.2016.12.010 |