التفاصيل البيبلوغرافية
| العنوان: |
Hematological and biochemical reference values for C57BL/6, Swiss Webster and BALB/c mice ; Valores de referência hematológicos e bioquímicos para camundongos das linhagens C57BL/6, Swiss Webster e BALB/c |
| المؤلفون: |
Santos, Ed Wilson, Oliveira, Dalila Cunha de, Hastreiter, Araceli, Silva, Graziela Batista da, Beltran, Jackeline Soares de Oliveira, Tsujita, Maristela, Crisma, Amanda Rabelo, Neves, Silvânia Meiry Peris, Fock, Ricardo Ambrósio, Borelli, Primavera |
| المصدر: |
Brazilian Journal of Veterinary Research and Animal Science; Vol. 53 Núm. 2 (2016); 138-145 ; Brazilian Journal of Veterinary Research and Animal Science; Vol. 53 No. 2 (2016); 138-145 ; Brazilian Journal of Veterinary Research and Animal Science; v. 53 n. 2 (2016); 138-145 ; 1678-4456 ; 1413-9596 |
| بيانات النشر: |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
| سنة النشر: |
2016 |
| المجموعة: |
Universidade de São Paulo: Portal de Revistas da USP |
| مصطلحات موضوعية: |
Hematology, Reference values, Mice, Hematologia, Valores de referência, Camundongos |
| الوصف: |
The use of animals in scientific research has contributed significantly to the development of science, promoting various advances in understanding the metabolic machinery and the discovery of treatments and preventive measures applied to human and veterinary medicine. The development and use of alternative methods is encouraged; however, in some situations, the use of animals in accordance with ethical policies is still required. Established hematological and clinical chemistry reference values in laboratory animals are essential to evaluate functional changes; however, there are few data in the literature on these values, being fundamentally a comparative basis. The aim of this investigation was the establishment of hematological and clinical chemistry reference values in common strains/stocks of mice used in animal experimentation. Blood profile (hemogram, reticulocytes and myelogram) and clinical chemistry serum determination of total protein, albumin, glucose, cholesterol, triglycerides, calcium and phosphorus were evaluated using C57BL/6, BALB/c and Swiss Webster mice, male, 2-3 months old. The results standardize reference intervals in animals reared in Laboratory Animal Facility, reflecting the expected condition in rodents subjected to scientific research. ; O uso de animais na pesquisa científica tem contribuído significativamente para o desenvolvimento da ciência, promovendo vários avanços na compreensão da maquinaria metabólica, bem como a descoberta de tratamentos e medidas preventivas aplicadas à medicina humana e veterinária. O desenvolvimento e utilização de métodos alternativos é encorajado, no entanto, em algumas situações, ainda é necessária a utilização de animais em conformidade com termos éticos. Estabelecer valores de referência hematológicos e bioquímicos para animais de laboratório é essencial para avaliar alterações funcionais, no entanto, existem poucos dados na literatura sobre estes valores, sendo fundamentalmente uma base comparativa. O presente trabalho foi delineado para ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://www.revistas.usp.br/bjvras/article/view/103850/114101Test; https://www.revistas.usp.br/bjvras/article/view/103850Test |
| الإتاحة: |
https://www.revistas.usp.br/bjvras/article/view/103850Test |
| حقوق: |
Copyright (c) 2016 Brazilian Journal of Veterinary Research and Animal Science |
| رقم الانضمام: |
edsbas.F68DB545 |
| قاعدة البيانات: |
BASE |
