المؤلفون: Rasco, Drew W., Medina, Theresa, Corrie, Pippa, Pavlick, Anna C., Middleton, Mark R., Lorigan, Paul, Hebert, Chris, Plummer, Ruth, Larkin, James, Agarwala, Sanjiv S., Daud, Adil I., Qiu, Jiaheng, Bozon, Viviana, Kneissl, Michelle, Barry, Elly, Olszanski, Anthony J.

المصدر: Cancer Chemotherapy & Pharmacology; Jul2023, Vol. 92 Issue 1, p15-28, 14p

مصطلحات موضوعية: IPILIMUMAB, MELANOMA, IMPRINTED polymers, EXENATIDE, SMALL molecules, ANTINEOPLASTIC agents, METASTASIS, TUMORS

المؤلفون: Gao, Shan, Bajrami, Ilirjana, Verrill, Clare, Kigozi, Asha, Ouaret, Djamila, Aleksic, Tamara, Asher, Ruth, Han, Cheng, Allen, Paul, Bailey, Deborah, Feller, Stephan, Kashima, Takeshi, Athanasou, Nicholas, Blay, Jean-Yves, Schmitz, Sandra, Machiels, Jean-Pascal, Upile, Nav, Jones, Terry M, Thalmann, George, Ashraf, Shazad Q, Wilding, Jennifer L, Bodmer, Walter F, Middleton, Mark R, Ashworth, Alan, Lord, Christopher J, Macaulay, Valentine M

المساهمون: UCL - (SLuc) Centre du cancer, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Service d'oto-rhino-laryngologie

المصدر: Cancer research, Vol. 74, no.20, p. 5866-77 (2014)

مصطلحات موضوعية: Adaptor Proteins, Signal Transducing, Animals, Antineoplastic Agents, Carcinoma, Squamous Cell, Cell Line, Tumor, Dishevelled Proteins, Drug Resistance, Neoplasm, Gene Expression, Head and Neck Neoplasms, Humans, Inhibitory Concentration 50, Insulin-Like Growth Factor I, Isoxazoles, MAP Kinase Signaling System, Male, Mice, Phosphoproteins, Pyrimidines, Receptor, IGF Type 1, Wnt Proteins, Xenograft Model Antitumor Assays, ras Proteins

العلاقة: boreal:245573; http://hdl.handle.net/2078.1/245573Test; info:pmid/25168481; urn:EISSN:1538-7445

الإتاحة: https://doi.org/10.1158/0008-5472.CAN-14-0806Test
http://hdl.handle.net/2078.1/245573Test

المؤلفون: Stratigos, Alexander J, Garbe, Claus, Dessinioti, Clio, Lebbe, Celeste, Bataille, Veronique, Bastholt, Lars, Dreno, Brigitte, Concetta Fargnoli, Maria, Forsea, Ana M, Frenard, Cecille, Harwood, Catherine A, Hauschild, Axel, Hoeller, Christoph, Kandolf-Sekulovic, Lidija, Kaufmann, Roland, Kelleners-Smeets, Nicole W J, Malvehy, Josep, Del Marmol, Veronique, Middleton, Mark R, Moreno-Ramirez, David, Pellecani, Giovanni, Peris, Ketty, Saiag, Philippe, van den Beuken-van Everdingen, Marieke H J, Vieira, Ricardo, Zalaudek, Iris, Eggermont, Alexander M M, Grob, Jean-Jacques, European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)

مصطلحات موضوعية: Anti-PD-1 antibody, Cemiplimab, Chemotherapy, Cutaneous squamous cell carcinoma, EGFR inhibitors, Follow-up, Locally advanced, Metastatic, Radiotherapy, Surgical excision, Treatment, Aftercare, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Immunological, Carcinoma, Squamous Cell, Chemoradiotherapy, Clinical Decision-Making, Consensus, Dermatologic Surgical Procedures, Dermatology, Humans, Lymph Node Excision, Lymph Nodes, Margins of Excision, Medical Oncology, Neoplasm Staging

العلاقة: http://hdl.handle.net/10668/15184Test

الإتاحة: https://doi.org/10.1016/j.ejca.2020.01.008Test
http://hdl.handle.net/10668/15184Test

المؤلفون: Middleton, Mark R.¹ (AUTHOR), Dean, Emma^2,3 (AUTHOR), Evans, Thomas R. J.⁴ (AUTHOR), Shapiro, Geoffrey I.⁵ (AUTHOR), Pollard, John^6,7 (AUTHOR), Hendriks, Bart S.^8,9 (AUTHOR), Falk, Martin^10,11 (AUTHOR), Diaz-Padilla, Ivan^12,13 (AUTHOR), Plummer, Ruth¹⁴ (AUTHOR) Ruth.Plummer@newcastle.ac.uk

المصدر: British Journal of Cancer. Aug2021, Vol. 125 Issue 4, p510-519. 10p.

مصطلحات موضوعية: *RESEARCH, *HETEROCYCLIC compounds, *RESEARCH methodology, *DEOXYCYTIDINE, *ANTINEOPLASTIC agents, *MEDICAL cooperation, *EVALUATION research, *TREATMENT effectiveness, *DRUG administration, *COMPARATIVE studies, *CISPLATIN, *SURVIVAL analysis (Biometry), *TUMORS

المؤلفون: Flaherty, Keith T, Robert, Caroline, Hersey, Peter, Nathan, Paul, Garbe, Claus, Milhem, Mohammed, Demidov, Lev V, Hassel, Jessica C, Rutkowski, Piotr, Mohr, Peter, Dummer, Reinhard, Trefzer, Uwe, Larkin, James M G, Utikal, Jochen, Dreno, Brigitte, Nyakas, Marta, Middleton, Mark R, Becker, Jürgen C, Casey, Michelle, Sherman, Laurie J, Wu, Frank S, Ouellet, Daniele, Martin, Anne-Marie, Patel, Kiran, Schadendorf, Dirk, METRIC Study Group

المساهمون: Schöffski, Patrick, U0046480, JLA

مصطلحات موضوعية: Adult, Aged, 80 and over, Antineoplastic Agents, Disease-Free Survival, Female, Humans, Intention to Treat Analysis, Kaplan-Meier Estimate, MAP Kinase Kinase 1, MAP Kinase Kinase 2, Male, Melanoma, Middle Aged, Mutation, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Pyridones, Pyrimidinones, Young Adult

العلاقة: New England Journal of Medicine vol:367 issue:2 pages:107-114; https://lirias.kuleuven.be/handle/123456789/361037Test

الإتاحة: https://lirias.kuleuven.be/handle/123456789/361037Test

المؤلفون: Watson, Amanda J, Sabharwal, Ami, Thorncroft, Mary R, McGown, Gail, Kerr, Richard, Bojanic, Stana, Soonawalla, Zahir, King, Alexandra, Miller, Andrea, Waller, Sue, Leung, Hing, Margison, Geoffrey P, Middleton, Mark R

المساهمون: Cancer Research UK Carcinogenesis Group, University of Manchester, Paterson Institute for Cancer Research, Manchester, United Kingdom.

مصطلحات موضوعية: Anticancerous Agents, Cancerous Gene Expression Regulation, Cancer, Administration, Oral, Adolescent, Adult, Aged, 80 and over, Antineoplastic Agents, Biomarkers, Pharmacological, Combined Modality Therapy, DNA Methylation, Dose-Response Relationship, Drug, Female, Gene Expression Regulation, Enzymologic, Neoplastic, Gene Silencing, Humans, Male, Middle Aged, Neoplasms, O(6)-Methylguanine-DNA Methyltransferase, Purines, Young Adult

العلاقة: Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib. 2010, 16 (2):743-9 Clin. Cancer Res.; http://hdl.handle.net/10541/109343Test; Clinical Cancer Research

الإتاحة: https://doi.org/10.1158/1078-0432.CCR-09-1389Test
http://hdl.handle.net/10541/109343Test

المؤلفون: Watson, Amanda J, Middleton, Mark R, McGown, Gail, Thorncroft, Mary R, Ranson, Malcolm R, Hersey, Peter, McArthur, Grant A, Davis, Ian D, Thomson, D, Beith, Jane, Haydon, Andrew, Kefford, Richard F, Lorigan, Paul C, Mortimer, Peter, Sabharwal, Ami, Hayward, O, Margison, Geoffrey P

المساهمون: Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK.

مصطلحات موضوعية: Cancer DNA, Antineoplastic Agents, Biopsy, DNA Damage, DNA Repair, DNA Replication, DNA, Neoplasm, Dacarbazine, Disease Progression, Humans, Kinetics, Melanoma, O(6)-Methylguanine-DNA Methyltransferase, Purines

العلاقة: O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib. 2009, 100 (8):1250-6 Br. J. Cancer; http://hdl.handle.net/10541/73959Test; British Journal of Cancer

الإتاحة: https://doi.org/10.1038/sj.bjc.6605015Test
http://hdl.handle.net/10541/73959Test

المؤلفون: Plummer, E Ruth, Middleton, Mark R, Jones, Christopher, Olsen, Anna, Hickson, Ian, McHugh, Peter, Margison, Geoffrey P, McGown, Gail, Thorncroft, Mary R, Watson, Amanda J, Boddy, Alan V, Calvert, A Hilary, Harris, Adrian L, Newell, David R, Curtin, Nicola J

المساهمون: Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom. E.R.Plummer@ncl.ac.uk

مصطلحات موضوعية: Cancer Metastasis, Adult, Aged, 80 and over, Antineoplastic Agents, Alkylating, Comet Assay, DNA Damage, DNA Methylation, DNA Repair, DNA, Neoplasm, Dacarbazine, Female, Headache, Humans, Lymphocytes, Male, Melanoma, Middle Aged, Neoplasm Metastasis, Neutropenia, O(6)-Methylguanine-DNA Methyltransferase, Poly(ADP-ribose) Polymerases, Thrombocytopenia, Time Factors, Treatment Outcome

العلاقة: Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1. 2005, 11 (9):3402-9 Clin. Cancer Res.; http://hdl.handle.net/10541/76293Test; Clinical Cancer Research

الإتاحة: https://doi.org/10.1158/1078-0432.CCR-04-2353Test
http://hdl.handle.net/10541/76293Test

المؤلفون: Hancock, Barry W, Wheatley, Keith, Harris, S, Ives, Natalie J, Harrison, G, Horsman, J M, Middleton, Mark R, Thatcher, Nick, Lorigan, Paul C, Marsden, J R, Burrows, L, Gore, M

المساهمون: Academic Unit of Clinical Oncology, The University of Sheffield, Weston Park Hospital, Whitham Rd, Sheffield S10 2SJ, UK. b.w.hancock@sheffield.ac.uk

مصطلحات موضوعية: Skin Cancer, Adolescent, Adult, Affect, Age Factors, Aged, 80 and over, Antineoplastic Agents, Disease-Free Survival, Dose-Response Relationship, Drug, Drug Administration Schedule, Fatigue, Female, Humans, Interferon-alpha, Male, Melanoma, Middle Aged, Risk Factors, Skin Neoplasms, Treatment Outcome

العلاقة: Adjuvant interferon in high-risk melanoma: the AIM HIGH Study--United Kingdom Coordinating Committee on Cancer Research randomized study of adjuvant low-dose extended-duration interferon Alfa-2a in high-risk resected malignant melanoma. 2004, 22 (1):53-61 J. Clin. Oncol.; http://hdl.handle.net/10541/77797Test; Journal of Clinical Oncology

الإتاحة: https://doi.org/10.1200/JCO.2004.03.185Test
http://hdl.handle.net/10541/77797Test

المؤلفون: Middleton, Mark R, Margison, Geoffrey P

المساهمون: Cancer Research UK Medical Oncology Unit, Churchill Hospital, Oxford, UK.

مصطلحات موضوعية: Cancer, Animals, Antineoplastic Agents, Alkylating, DNA Damage, DNA Repair, Drug Resistance, Neoplasm, Humans, Neoplasms, Nucleotidyltransferases, O(6)-Methylguanine-DNA Methyltransferase

العلاقة: Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway. 2003, 4 (1):37-44 Lancet Oncol.; http://hdl.handle.net/10541/82335Test; The Lancet Oncology

الإتاحة: http://hdl.handle.net/10541/82335Test