التفاصيل البيبلوغرافية
| العنوان: |
Parkinson disease with mild cognitive impairment: Domain‐specific cognitive complaints predict dementia |
| المؤلفون: |
Gasca‐Salas, Carmen, Duff‐Canning, Sarah, Armstrong, Melissa J, Eslinger, Paul J, Schneider, Ruth B, Kennedy, Nancy, Chou, Kelvin L, Persad, Carol, Litvan, Irene, Weintraub, Sandra, Marras, Connie |
| المصدر: |
Acta Neurologica Scandinavica, vol 142, iss 6 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2020 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Parkinson's Disease, Alzheimer's Disease, Mental Health, Aging, Acquired Cognitive Impairment, Clinical Research, Neurodegenerative, Behavioral and Social Science, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Dementia, Neurological, Aged, 80 and over, Cohort Studies, Disease Progression, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease, Retrospective Studies, Symptom Assessment, cognitive complaint, mild cognitive impairment, Parkinson ' s disease |
| جغرافية الموضوع: |
585 - 596 |
| الوصف: |
BackgroundThe presence of subjective cognitive complaints (SCC) as a predictor of cognitive impairment in Parkinson´s disease (PD) has shown conflicting results. Most previous studies only assessed complaints in the memory domain. We investigate the association of SCCs across cognitive domains with development of mild cognitive impairment (PD-MCI) and dementia (PDD) in PD and to assess agreement between SCCs and objective cognitive impairments in this population.MethodsThis is a retrospective analysis of a prospective cohort study. Participants were enrolled at six North-American movement disorders centers. They underwent neuropsychological and non-cognitive clinical evaluations, including the modified Neurobehavioral Inventory to elicit SCC (rated by each patient and independently by their close contact (CC)). Associations between SCCs and development of future cognitive impairment were assessed. Agreement between SCCs and objective impairment within the same domain was also calculated.ResultsOf 138 included PD patients, 42% fulfilled criteria for PD-MCI. None of the NBI items predicted development of cognitive impairment after one and two years in PD with normal cognition. In PD-MCI patients, SCCs related to attention predicted dementia at year one. CC ratings of SCCs related to memory and language problems predicted PDD in PD-MCI patients. According to CC reported patients' complaints, there was a significant agreement between SCCs and objective cognitive test scores on attention.ConclusionsEliciting SCCs including cognitive domains other than memory is crucial for a complete evaluation, including both patient and CC report. Memory, language, and especially attention SCCs in PD-MCI may predict progression to dementia. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
qt4vn6h56m; https://escholarship.org/uc/item/4vn6h56mTest |
| الإتاحة: |
https://escholarship.org/uc/item/4vn6h56mTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.D67B897E |
| قاعدة البيانات: |
BASE |
