التفاصيل البيبلوغرافية
| العنوان: |
PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation |
| المؤلفون: |
Petrelli, Alessandra, Mijnheer, Gerdien, Hoytema Van Konijnenburg, David P., Van Der Wal, Maria M., Giovannone, Barbara, Mocholi, Enric, Vazirpanah, Nadia, Broen, Jasper C., Hijnen, Dirkjan, Oldenburg, Bas, Coffer, Paul J., Vastert, Sebastian J., Prakken, Berent J., Spierings, Eric, Pandit, Aridaman, Mokry, Michal, Van Wijk, Femke |
| المساهمون: |
MMB Research line 1, Infection & Immunity, Lab Dermatologie/Allergologie, Cancer, CMM Groep Coffer, Translationele immunologie, Unit Opleiding Reumat./Klin. Immunologie, MS MDL 1, Onderzoek, CMM Sectie Stem Cells, Regenerative Medicine and Stem Cells, Immuno/reuma onderzoek 5 (Vastert2), Child Health, Immuno/reuma patientenzorg, Circulatory Health, CDL Patiëntenzorg MI, MDL onderzoek 1, Immuno/reuma onderzoek 4 |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
Adolescent, Adult, CD8-Positive T-Lymphocytes/immunology, Child, Preschool, Chronic Disease, Female, Humans, Immunologic Memory, Infant, Inflammation, Male, Programmed Cell Death 1 Receptor/immunology, General Medicine, Clinical Trial, Research Support, Non-U.S. Gov't, Journal Article |
| الوصف: |
Chronic inflammatory diseases are characterized by recurrent inflammatory attacks in the tissues mediated by autoreactive T cells. Identity and functional programming of CD8+ T cells at the target site of inflammation still remain elusive. One key question is whether, in these antigen-rich environments, chronic stimulation leads to CD8+ T cell exhaustion comparable to what is observed in infectious disease contexts. In the synovial fluid (SF) of juvenile idiopathic arthritis (JIA) patients, a model of chronic inflammation, an overrepresentation of PD-1+CD8+ T cells was found. Gene expression profiling, gene set enrichment analysis, functional studies, and extracellular flux analysis identified PD-1+CD8+ T cells as metabolically active effectors, with no sign of exhaustion. Furthermore, PD-1+CD8+ T cells were enriched for a tissue-resident memory (Trm) cell transcriptional profile and demonstrated increased clonal expansion compared with the PD-1- counterpart, suggesting antigen-driven expansion of locally adapted cells. Interestingly, this subset was also found increased in target tissues in other human chronic inflammatory diseases. These data indicate that local chronic inflammation drives the induction and expansion of CD8+ T cells endowed with potential detrimental properties. Together, these findings lay the basis for investigation of PD-1-expressing CD8+ T cell targeting strategies in human chronic inflammatory diseases. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0021-9738 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/372974Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/372974Test |
| حقوق: |
info:eu-repo/semantics/ClosedAccess |
| رقم الانضمام: |
edsbas.7B982110 |
| قاعدة البيانات: |
BASE |
Full Text Finder