Objective: The research objective is the comparison of levels of serum alanine aminotransferase at 12th vs. 24th week, with the reference of normalization, after interferon treatment has begun among the patients of chronic hepatitis C. Patients and Methods: The study (Quasi-experimental) was conducted at the Medicine Department of Services Hospital, Lahore from June 2016 to April 2017. The subject size of 250 patients with chronic hepatitis C was selected to compare ALT serum in accordance with normalization at twelfth week vs. 24th week after ribavirin and interferon therapy has begun. Results: The mean age of 250 subjects was (47.5 ± 06.7) years with the number of male and female patients as 54% (136) and 46% (114) respectively. Normal SAAL was recorded among 88% (220) patients at 12th week and 96% (240) patients at 24th week after the treatment of interferon started. Significant (p-value=0.001) difference was recorded at twelfth and 24th week, in terms of SAAL of normalization. Conclusion: Normalization of SAAL was found distinctly higher at 24th week after the treatment has begun as compare to the 12th week. Keywords: Hepatitis C Virus (HCV), Ribavirin & Interferon Therapy (R&IT), Serum Alanine Aminotransferase Levels (SAAL), Chronic Hepatitis C (CHC).
