A step towards international prospective trials in carbon ion radiotherapy: investigation of factors influencing dose distribution in the facilities in operation based on a case of skull base chordoma
| العنوان: | A step towards international prospective trials in carbon ion radiotherapy: investigation of factors influencing dose distribution in the facilities in operation based on a case of skull base chordoma |
|---|---|
| المؤلفون: | Vogin, G., Wambersie, A., Koto, M., Ohno, T., Uhl, M., Fossati, P., Balosso, J., on behalf of ULICE WP2 working group |
| المساهمون: | UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de radiologie |
| المصدر: | Radiation Oncology, Vol 14, Iss 1, Pp 1-12 (2019) Radiation Oncology, Vol. 14, no. 1, p. 24 [1-12] (2019) Radiation Oncology (London, England) |
| بيانات النشر: | Zenodo, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Organs at Risk, lcsh:Medical physics. Medical radiology. Nuclear medicine, medicine.medical_specialty, lcsh:R895-920, Planning target volume, Equieffective dose, Heavy Ion Radiotherapy, Dose distribution, Clinical trials methodology, Radiotherapy Setup Errors, Skull Base Neoplasms, lcsh:RC254-282, Patient Positioning, Clival Chordoma, 03 medical and health sciences, 610 Medical sciences Medicine, 0302 clinical medicine, Beam delivery, Chordoma, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Medical physics, Prospective Studies, Radiation treatment planning, Dose delivery, business.industry, Radiotherapy Planning, Computer-Assisted, Research, Radiotherapy Dosage, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Oncology, Radiology Nuclear Medicine and imaging, Carbon ion radiotherapy, 030220 oncology & carcinogenesis, Carbon Ion Radiotherapy, business, Quality assurance |
| الوصف: | Background: Carbon ion radiotherapy (CIRT) has been delivered to more than 20,000 patients worldwide. International trials have been recommended in order to emphasize the actual benefits. The ULICE program (Union of Light Ion Centers in Europe) addressed the need for harmonization of CIRT practices. A comparative knowledge of the sources and magnitudes of uncertainties altering dose distribution and clinical effects during the whole CIRT procedure is required in that aim.Methods: As part of ULICE WP2 task group, we sent a centrally reviewed questionnaire exploring candidate sources of uncertainties in dose deposition to the ten CIRT facilities in operation by February 2017. We aimed to explore native beam characterization, immobilization, anatomic data acquisition, target volumes and organs at risks delineation, treatment planning, dose delivery, quality assurance prior and during treatment. The responders had to consider the clinical case of a clival chordoma eligible for postoperative CIRT according to their clinical practice. With the results, our task group discussed ways to harmonize CIRT practices.Results: We received 5 surveys from facilities that have treated 77% of the patients worldwide per November 2017. We pointed out the singularity of the facilities and beam delivery systems, a divergent definition of target volumes, the multiplicity of TPS and equieffective dose calculation approximations.Conclusion: Multiple uncertainties affect equieffective dose definition, deposition and calculation in CIRT. Although it is not possible to harmonize all the steps of the CIRT planning between the centers, our working group proposed counter-measures addressing the improvable limitations. |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727a3ec15f081e3fb49ed1997bc87870Test https://zenodo.org/record/2556433Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....727a3ec15f081e3fb49ed1997bc87870 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |