An asymmetrical sharing of adhesion molecules throughout the cell surface of the M. tuberculosis and their significant associative role in host-pathogen interaction remains elusive. The continual researches in host-pathogen interaction mechanism revealed certain potential adhesins that facilitates mycobacterium adherence to host cells surface. The adhesion proteins like fibronectin binding protein (fnbp) are expressed by PE_PGRS a polymorphic GC-repetitive sequence belong to subfamily in M. tuberculosis which have a potential role in cell-attachment, entry, and immune evasion. This review addresses the adhesion property of fnbp in M. tuberculosis and their role in cell-cell adhesion process. Additionally modulation of host’s cells signaling to promotes adhesion and host-pathogen interaction events. Likewise, this study highlights the prominent role of fnbp that may further act as a potent source of antigenic variation lead to evoke immune response during mycobacterium infection. So, increasing in our current understanding in these selective fnbp (adhesion proteins) and by targeting these M. tuberculosis expressive genes could help us for development of novel drug that will further valuable for therapeutics.
