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Krajewski Piotr, Krajewska Agata, Żukowska Magdalena. Breast cancer in a male patient with a BRCA1 mutation - a case report. Journal of Education, Health and Sport. 2018;8(9):658-661 eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1412464Test http://ojs.ukw.edu.pl/index.php/johs/article/view/5947Test https://pbn.nauka.gov.pl/sedno-webapp/works/876687Test The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eissn 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0Test/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.08.2018. Revised: 18.08.2018. Accepted: 10.09.2018. Breast cancer in a male patient with a BRCA1 mutation - a case report Piotr Krajewski1, Agata Krajewska2, Magdalena Żukowska3 1Pomeranian University of Medicine, Doctoral Studies Faculty of Medicine and Dentistry 2Pomeranian Medical University, Doctoral College Medical Faculty 3Pomeranian Medical University, Doctoral Studies Faculty of Health Sciences Abstract A 71-year-old patient with BRCA 1 mutation and breast cancer diagnosed in prophylactic screening. This case shows how crucial prophylactic screening is. BRCA1-positive patients, both men and women, need to be under special care, hence the diagnostic process and treatment should take place inhighly specialized centers. Introduction The mutation in the BRCA 1 gene in women increases the risk of developing breast and ovarian cancer. In men, it is mainly associated with an increased risk of the fallopian tube, colon and prostate cancer. Men account for 1% of breast cancer patients, very often its occurrence is associated with a high penetration of the mutation in the BRCA 1 gene and the familial occurrence of breast cancer.[1,2] The curability of breast cancer is closely correlated to the severity of the disease at the time of detection.[3] Case report In a 71-year-old patient with BRCA 1 mutation, prophylactic screening led to the detection of the breast cancer. After the diagnosis, the patient underwent right-sided mastectomy and a diagnostic excision of the sentinel lymph node from the right axillary cavity. At three years of follow-up, the patient is considered to have no recurrence of the neoplastic disease. Discussion Current knowledge of breast cancer in men with the BRCA 1 gene mutation is limited. Usually the disease is detected at a late stage, which results in a small chance of curing the disease. Prophylactic treatment in such patients should include systematic control in Oncological Out-patient departments, by breast imaging in ultrasonography and mammography. A prophylactic mastectomy could be seen as a controversial preventive method that reduces the risk of breast cancer in men with a BRCA 1 gene mutation. It is a method that involves significant mutilation and the indications for its use require further research. Keywords:BRCA 1; breast cancer in men |
